Evidence of intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells

Judith R. Mourant; Andreas H. Hielscher; Angelia A. Eick; Tamara M. Johnson; James P. Freyer

doi:10.1002/(SICI)1097-0142(19981225)84:6<366::AID-CNCR9>3.0.CO;2-7

Evidence of intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells

Judith R. Mourant, Andreas H. Hielscher, Angelia A. Eick, Tamara M. Johnson, James P. Freyer

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND. The objective of this study was to determine whether there are intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells from a multistep carcinogenesis model. METHODS. Wavelength-dependent and polarization-dependent light scattering properties of cell suspensions were measured. RESULTS. Statistically significant differences were found between the tumorigenic and nontumorigenic cells. CONCLUSIONS. Differences in the light scattering properties of tumorigenic and nontumorigenic cells are attributed to a change in the average size of the scattering centers on the order of a few ten of nanometers. This work is relevant to the development of noninvasive optical methods for cancer diagnosis.

Original language	English (US)
Pages (from-to)	366-374
Number of pages	9
Journal	Cancer
Volume	84
Issue number	6
DOIs	https://doi.org/10.1002/(SICI)1097-0142(19981225)84:6<366::AID-CNCR9>3.0.CO;2-7
State	Published - Dec 25 1998

Keywords

Cancer diagnosis
Light scattering
Tumorigenesis models
Turbid media

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/(SICI)1097-0142(19981225)84:6<366::AID-CNCR9>3.0.CO;2-7

Cite this

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title = "Evidence of intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells",

abstract = "BACKGROUND. The objective of this study was to determine whether there are intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells from a multistep carcinogenesis model. METHODS. Wavelength-dependent and polarization-dependent light scattering properties of cell suspensions were measured. RESULTS. Statistically significant differences were found between the tumorigenic and nontumorigenic cells. CONCLUSIONS. Differences in the light scattering properties of tumorigenic and nontumorigenic cells are attributed to a change in the average size of the scattering centers on the order of a few ten of nanometers. This work is relevant to the development of noninvasive optical methods for cancer diagnosis.",

keywords = "Cancer diagnosis, Light scattering, Tumorigenesis models, Turbid media",

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T1 - Evidence of intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells

AU - Mourant, Judith R.

AU - Hielscher, Andreas H.

AU - Eick, Angelia A.

AU - Johnson, Tamara M.

AU - Freyer, James P.

PY - 1998/12/25

Y1 - 1998/12/25

N2 - BACKGROUND. The objective of this study was to determine whether there are intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells from a multistep carcinogenesis model. METHODS. Wavelength-dependent and polarization-dependent light scattering properties of cell suspensions were measured. RESULTS. Statistically significant differences were found between the tumorigenic and nontumorigenic cells. CONCLUSIONS. Differences in the light scattering properties of tumorigenic and nontumorigenic cells are attributed to a change in the average size of the scattering centers on the order of a few ten of nanometers. This work is relevant to the development of noninvasive optical methods for cancer diagnosis.

AB - BACKGROUND. The objective of this study was to determine whether there are intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells from a multistep carcinogenesis model. METHODS. Wavelength-dependent and polarization-dependent light scattering properties of cell suspensions were measured. RESULTS. Statistically significant differences were found between the tumorigenic and nontumorigenic cells. CONCLUSIONS. Differences in the light scattering properties of tumorigenic and nontumorigenic cells are attributed to a change in the average size of the scattering centers on the order of a few ten of nanometers. This work is relevant to the development of noninvasive optical methods for cancer diagnosis.

KW - Cancer diagnosis

KW - Light scattering

KW - Tumorigenesis models

KW - Turbid media

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Evidence of intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells

Abstract

Keywords

ASJC Scopus subject areas

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