Evolution in microbes

Research output: Contribution to journalReview articlepeer-review


This review presents a broad survey of experimental microbial evolution, covering diverse topics including trade-offs, epistasis, fluctuating conditions, spatial dynamics, cooperation, aging, and stochastic switching. Emphasis is placed on examples that highlight key conceptual points or address theoretical predictions. Experimental evolution is discussed from two points of view. First, population trajectories are described as adaptive walks on a fitness landscape, whose genetic structure can be probed by experiments. Second, populations are viewed from a physiological perspective, and their nongenetic heterogeneity is examined. Bringing together these two viewpoints remains a major challenge for the future.

Original languageEnglish (US)
Pages (from-to)493-514
Number of pages22
JournalAnnual Review of Biophysics
Issue number1
StatePublished - May 2013


  • bacteria
  • cooperation
  • ecology
  • evolutionary dynamics
  • experimental evolution
  • fitness
  • physiology
  • yeast

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Bioengineering
  • Biochemistry
  • Cell Biology


Dive into the research topics of 'Evolution in microbes'. Together they form a unique fingerprint.

Cite this