TY - JOUR
T1 - Evolutionary and biomedical implications of sex differences in the primate brain transcriptome
AU - Cayo Biobank Research Unit
AU - DeCasien, Alex R.
AU - Chiou, Kenneth L.
AU - Testard, Camille
AU - Mercer, Arianne
AU - Negrón-Del Valle, Josué E.
AU - Bauman Surratt, Samuel E.
AU - González, Olga
AU - Stock, Michala K.
AU - Ruiz-Lambides, Angelina V.
AU - Martínez, Melween I.
AU - Antón, Susan C.
AU - Walker, Christopher S.
AU - Sallet, Jérôme
AU - Wilson, Melissa A.
AU - Brent, Lauren J.N.
AU - Montague, Michael J.
AU - Sherwood, Chet C.
AU - Platt, Michael L.
AU - Higham, James P.
AU - Snyder-Mackler, Noah
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024/7/10
Y1 - 2024/7/10
N2 - Humans exhibit sex differences in the prevalence of many neurodevelopmental disorders and neurodegenerative diseases. Here, we generated one of the largest multi-brain-region bulk transcriptional datasets for the rhesus macaque and characterized sex-biased gene expression patterns to investigate the translatability of this species for sex-biased neurological conditions. We identify patterns similar to those in humans, which are associated with overlapping regulatory mechanisms, biological processes, and genes implicated in sex-biased human disorders, including autism. We also show that sex-biased genes exhibit greater genetic variance for expression and more tissue-specific expression patterns, which may facilitate rapid evolution of sex-biased genes. Our findings provide insights into the biological mechanisms underlying sex-biased disease and support the rhesus macaque model for the translational study of these conditions.
AB - Humans exhibit sex differences in the prevalence of many neurodevelopmental disorders and neurodegenerative diseases. Here, we generated one of the largest multi-brain-region bulk transcriptional datasets for the rhesus macaque and characterized sex-biased gene expression patterns to investigate the translatability of this species for sex-biased neurological conditions. We identify patterns similar to those in humans, which are associated with overlapping regulatory mechanisms, biological processes, and genes implicated in sex-biased human disorders, including autism. We also show that sex-biased genes exhibit greater genetic variance for expression and more tissue-specific expression patterns, which may facilitate rapid evolution of sex-biased genes. Our findings provide insights into the biological mechanisms underlying sex-biased disease and support the rhesus macaque model for the translational study of these conditions.
KW - animal model
KW - autism
KW - brain evolution
KW - comparative neurobiology
KW - rhesus macaque
KW - sex-biased gene expression
UR - http://www.scopus.com/inward/record.url?scp=85197563072&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85197563072&partnerID=8YFLogxK
U2 - 10.1016/j.xgen.2024.100589
DO - 10.1016/j.xgen.2024.100589
M3 - Article
AN - SCOPUS:85197563072
SN - 2666-979X
VL - 4
JO - Cell Genomics
JF - Cell Genomics
IS - 7
M1 - 100589
ER -