Evolving proteins of novel composition

Jin Kim Montclare, David A. Tirrell

Research output: Contribution to journalArticlepeer-review


(Chemical Equation Presented) Changing its nature: Global incorporation of noncanonical amino acids can alter the behavior of proteins in useful ways. In some cases, however, replacement of natural amino acids by noncanonical analogues (blue bars in picture) can cause loss of protein stability. After several generations, functional proteins of non-natural composition were prepared through residue-specific incorporation combined with directed evolution.

Original languageEnglish (US)
Pages (from-to)4518-4521
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number27
StatePublished - Jul 3 2006


  • Amino acids
  • Directed evolution
  • Enzymes
  • Protein engineering
  • Thermostability

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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