TY - JOUR
T1 - Excitation dynamics
T2 - Insights from simplified membrane models
AU - Rinzel, J.
N1 - Copyright:
Copyright 2004 Elsevier B.V., All rights reserved.
PY - 1985
Y1 - 1985
N2 - Excitable nerve membranes and models for their electrical activity exhibit a broad repertoire of dynamic behavior. To reveal these behaviors the theoretician seeks a model that is simple enough to analyze yet one that retains adequate biophysical realism. Here we strike such a balance by describing a two-variable simplification of the Hodgkin-Huxley (HH) model, which exhibits many membrane phenomena and reproduces, with good agreement, many HH responses. Comparisons and illustrations are presented for the single spike response, repetitive firing (and its cessation by a brief current pulse), and bistable behavior for increased extracellular K+ concentrations.
AB - Excitable nerve membranes and models for their electrical activity exhibit a broad repertoire of dynamic behavior. To reveal these behaviors the theoretician seeks a model that is simple enough to analyze yet one that retains adequate biophysical realism. Here we strike such a balance by describing a two-variable simplification of the Hodgkin-Huxley (HH) model, which exhibits many membrane phenomena and reproduces, with good agreement, many HH responses. Comparisons and illustrations are presented for the single spike response, repetitive firing (and its cessation by a brief current pulse), and bistable behavior for increased extracellular K+ concentrations.
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M3 - Article
C2 - 2415401
AN - SCOPUS:0022332422
SN - 0014-9446
VL - 44
SP - 2944
EP - 2946
JO - Federation Proceedings
JF - Federation Proceedings
IS - 15
ER -