Excitation-inhibition discoordination in rodent models of mental disorders

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Animal models of mental illness provide a foundation for evaluating hypotheses for the mechanistic causes of mental illness. Neurophysiological investigations of neural network activity in rodent models of mental dysfunction are reviewed from the conceptual framework of the discoordination hypothesis, which asserts that failures of neural coordination cause cognitive deficits in the judicious processing and use of information. Abnormal dynamic coordination of excitatory and inhibitory neural discharge in pharmacologic and genetic rodent models supports the discoordination hypothesis. These observations suggest excitation-inhibition discoordination and aberrant neural circuit dynamics as causes of cognitive impairment, as well as therapeutic targets for cognition-promoting treatments.

Original languageEnglish (US)
Pages (from-to)1079-1088
Number of pages10
JournalBiological Psychiatry
Issue number12
StatePublished - Jun 15 2015


  • Discoordination
  • Excitation-inhibition coupling
  • Neural coordination
  • Neural ensemble
  • Neural synchrony
  • Oscillations

ASJC Scopus subject areas

  • Biological Psychiatry


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