Experimental Use of Semiconductor Diode Laser in Contact Transscleral Cyclophotocoagulation in Rabbits

Joel S. Schuman, John J. Jacobson, Carmen A. Puliafito, Robert J. Noecker, Wini T. Reidy

Research output: Contribution to journalArticlepeer-review


Acute and long-term effects of contact transscleral semiconductor diode laser cyclophotocoagulation were studied in rabbits. Immediately following cyclophotocoagulation, light microscopy revealed coagulation necrosis of the ciliary pigmented and nonpigmented epithelia and stroma; destruction increased in relation to power. There was architectural disruption with higher energy levels. The findings with diode and continuous-wave contact neodymium-YAG lasers were similar. In rabbits treated and followed up for 6 weeks there was a decrease in intraocular pressure during the observation period (P <.05, paired Student's t test). The gross and light microscopic examination revealed focal atrophy and fibrosis of the ciliary processes, with pigment-laden macrophages on the ciliary processes and in the outflow pathways. Higher energy levels caused lens capsule damage and vitritis. The diode laser produced ciliary destruction similar to the continuous-wave contact neodymium-YAG laser in rabbits, with significant intraocular pressure lowering during the 6-week follow-up.

Original languageEnglish (US)
Pages (from-to)1152-1157
Number of pages6
JournalArchives of Ophthalmology
Issue number8
StatePublished - Aug 1990

ASJC Scopus subject areas

  • Ophthalmology


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