Exploiting gene expression variation to capture gene-environment interactions for disease

Youssef Idaghdour, Philip Awadalla

Research output: Contribution to journalArticlepeer-review


Gene-environment interactions have long been recognized as a fundamental concept in evolutionary, quantitative, and medical genetics. In the genomics era, study of how environment and genome interact to shape gene expression variation is relevant to understanding the genetic architecture of complex phenotypes. While genetic analysis of gene expression variation focused on main effects, little is known about the extent of interaction effects implicating regulatory variants and their consequences on transcriptional variation. Here we survey the current state of the concept of transcriptional gene-environment interactions and discuss its utility for mapping disease phenotypes in light of the insights gained from genome-wide association studies of gene expression.

Original languageEnglish (US)
Article numberArticle 228
JournalFrontiers in Genetics
Issue numberMAY
StatePublished - 2013


  • Gene-environment interactions
  • Transcriptome
  • eQTL
  • eSNP

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Genetics(clinical)


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