Exploring the chemoresistance mechanisms of leukemia in a biomimetic 'leukemia-on-a-chip' microsystem

Chao Ma, Weiqiang Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

B-cell acute lymphoblastic leukemia (B-ALL) is the most common cancer among children. The survival rate of B-ALL patients has improved dramatically through chemotherapy, however, relapsed B-ALL remains a leading cause of cancer-related death in children. To address this, existing treatment strategies have exploited tumor-intrinsic survival mechanisms to develop targeted therapy, however, they do not account for the “leukemic bone marrow niche” that may maintain leukemia progression. Herein, we described a 3D biomimetic 'Leukemia-on-a-Chip' platform to investigate the critical leukemia-bone marrow interactions in regulating chemotherapy resistance.

Original languageEnglish (US)
Title of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PublisherChemical and Biological Microsystems Society
Pages152-153
Number of pages2
ISBN (Electronic)9781510897571
StatePublished - 2018
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan, Province of China
Duration: Nov 11 2018Nov 15 2018

Publication series

Name22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Volume1

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
CountryTaiwan, Province of China
CityKaohsiung
Period11/11/1811/15/18

Keywords

  • Bone marrow
  • Chemoresistance
  • Leukemia-on-a-Chip
  • Microfluidics

ASJC Scopus subject areas

  • Chemistry(all)
  • Bioengineering
  • Chemical Engineering (miscellaneous)
  • Control and Systems Engineering

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  • Cite this

    Ma, C., & Chen, W. (2018). Exploring the chemoresistance mechanisms of leukemia in a biomimetic 'leukemia-on-a-chip' microsystem. In 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 (pp. 152-153). (22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018; Vol. 1). Chemical and Biological Microsystems Society.