TY - GEN
T1 - Exploring the chemoresistance mechanisms of leukemia in a biomimetic 'leukemia-on-a-chip' microsystem
AU - Ma, Chao
AU - Chen, Weiqiang
N1 - Funding Information:
We acknowledge financial support from the Department of Mechanical and Aerospace Engineering at New York University and the American Heart Association Scientist Development Grant (16SDG31020038).
Publisher Copyright:
Copyright© (2018) by Chemical and Biological Microsystems Society.All rights reserved.
PY - 2018
Y1 - 2018
N2 - B-cell acute lymphoblastic leukemia (B-ALL) is the most common cancer among children. The survival rate of B-ALL patients has improved dramatically through chemotherapy, however, relapsed B-ALL remains a leading cause of cancer-related death in children. To address this, existing treatment strategies have exploited tumor-intrinsic survival mechanisms to develop targeted therapy, however, they do not account for the “leukemic bone marrow niche” that may maintain leukemia progression. Herein, we described a 3D biomimetic 'Leukemia-on-a-Chip' platform to investigate the critical leukemia-bone marrow interactions in regulating chemotherapy resistance.
AB - B-cell acute lymphoblastic leukemia (B-ALL) is the most common cancer among children. The survival rate of B-ALL patients has improved dramatically through chemotherapy, however, relapsed B-ALL remains a leading cause of cancer-related death in children. To address this, existing treatment strategies have exploited tumor-intrinsic survival mechanisms to develop targeted therapy, however, they do not account for the “leukemic bone marrow niche” that may maintain leukemia progression. Herein, we described a 3D biomimetic 'Leukemia-on-a-Chip' platform to investigate the critical leukemia-bone marrow interactions in regulating chemotherapy resistance.
KW - Bone marrow
KW - Chemoresistance
KW - Leukemia-on-a-Chip
KW - Microfluidics
UR - http://www.scopus.com/inward/record.url?scp=85079874115&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85079874115&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85079874115
T3 - 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
SP - 152
EP - 153
BT - 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PB - Chemical and Biological Microsystems Society
T2 - 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Y2 - 11 November 2018 through 15 November 2018
ER -