Exploring the Evidence: Symptom Burden in Chronic Kidney Disease

Maya N. Clark-Cutaia, Eleanor Rivera, Christin Iroegbu, Gavin Arneson, Rebecca Deng, Joyce K. Anastasi

Research output: Contribution to journalArticlepeer-review


Chronic kidney disease (CKD) is more prevalent in individuals with obesity, diabetes mellitus, or hypertension. Individuals with CKD are prone to kidney failure, with symptom experiences that rival those of patients with cancer. We explored symptom burden in individuals with CKD via a systematic review of 30 quantitative and qualitative articles. The most common CKD symptoms were fatigue, weakness, pain, sleep disturbances and itchy skin. Instruments used to assess symptoms were the Kidney Disease Quality of Life (KDQOL)-36, the Palliative Outcome Symptom-Scale renal (POS-r)-13, and the Dialysis Symptom Index (DSI)-10. The included qualitative studies expand and expound on the quantitative data presented. This article describes the prevalence of symptom burden in individuals with CKD in relation to psychosocial and demographic factors and discuss the importance of symptom management.

Original languageEnglish (US)
Pages (from-to)227-255
Number of pages29
JournalNephrology nursing journal : journal of the American Nephrology Nurses' Association
Issue number3
StatePublished - May 1 2022


  • chronic kidney disease
  • hemodialysis
  • kidney failure
  • pain
  • sleep disturbance
  • symptom
  • symptom burden
  • systematic review

ASJC Scopus subject areas

  • General Medicine


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