Expression of collagen binding integrins during cardiac development and hypertrophy

L. Terracio, K. Rubin, D. Gullberg, E. Balog, W. Carver, R. Jyring, T. K. Borg

    Research output: Contribution to journalArticlepeer-review


    The interaction between components of the extracellular matrix and the cell surface of cardiac myocytes appears to be regulated in part by receptors belonging to the integrin superfamily. The expression of the integrins was investigated at different stages of development of the heart as well as during cardiac hypertrophy. The characterization of the membrane proteins showed that a β1-integrin and associated α-chains were responsible for the interaction with collagen, laminin, and fibronectin. Immunoprecipitation data indicated that the presence of specific α-chains varied with development. These data were correlated with the ability of the isolated myocytes to attach to specific components of the extracellular matrix. The expression of the α1-chain was prominently associated with the recognition of interstitial collagens. The presence of the α1-chain was also associated with stages when collagen synthesis was increased, especially during letal and neonatal growth and cardiac hypertrophy. Immunohistochemical localization with the antiserum against β1-integrin demonstrated its specific localization near the Z lines of cardiac myocytes. The localization both in vitro and in vivo indicated that the β1-integrin may play a role in myofibrillogenesis during development. The present immunohistochemical, cell adhesion, and biochemical data clearly indicate that integrins play a major role in the regulation of the interaction between cardiac myocytes and the extracellular matrix during development and disease.

    Original languageEnglish (US)
    Pages (from-to)734-744
    Number of pages11
    JournalCirculation research
    Issue number3
    StatePublished - 1991


    • cardiac development
    • cardiac hypertrophy
    • collagen binding
    • extracellular matrix
    • integrins

    ASJC Scopus subject areas

    • Physiology
    • Cardiology and Cardiovascular Medicine


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