TY - JOUR
T1 - Expression of serotonergic receptors in psoriatic skin
AU - Nordlind, Klas
AU - Thorslund, Kristoffer
AU - Lonne-Rahm, Solbritt
AU - Mohabbati, Sheila
AU - Berki, Timea
AU - Morales, Marisela
AU - Azmitia, Efrain C.
N1 - Funding Information:
Acknowledgements This study was supported by grants from the Swedish Foundation for Health Care Sciences and Allergy Research, the Swedish Psoriasis Association, the Ekhaga Foundation, MH55250 (ECA), the Magnus Bergwall Foundation and the We-lander/Finsen Foundation, and the Karolinska Institutet. The technical skilfulness of Mrs. Eva Hagforsen is gratefully acknowledged.
PY - 2006/8
Y1 - 2006/8
N2 - Psoriasis appears to be influenced by stress, which causes release of adrenal hormones. Serotonin, or hormonal actions on serotonin and serotonin receptors, may have a role in psoriasis. Distribution of serotonin receptors was studied in involved and noninvolved skin in patients with psoriasis and compared to normal skin, by using immunohistochemistry and antibodies to 5-HT1A, 5-HT2A and 5-HT3 receptors (R). There was a decreased (P<0.001) number of 5-HT1AR positive cells, the majority being tryptase positive, in involved and noninvolved psoriatic papillary dermis, compared to normal skin. 5-HTlAR expression was also found in the upper part of the epidermis, on vessel walls and on melanocytes. 5-HT2AR expressing papillary mononuclear cells, CD3 positive, were increased (P<0.001 and P<0.01, respectively) in involved and noninvolved psoriatic skin, compared to normal skin, an increase (P<0.01) also being found in the involved compared to noninvolved skin. Expression of 5-HT3R could be found in the basal epidermal layer of noninvolved but not in the involved skin of psoriasis, where it was only found in the acrosyringium. The present findings are compatible with the 5-HT1A and 5-HT2A receptors having antagonistic functions, and raise the possibility of using receptor specific drugs in the treatment of psoriasis.
AB - Psoriasis appears to be influenced by stress, which causes release of adrenal hormones. Serotonin, or hormonal actions on serotonin and serotonin receptors, may have a role in psoriasis. Distribution of serotonin receptors was studied in involved and noninvolved skin in patients with psoriasis and compared to normal skin, by using immunohistochemistry and antibodies to 5-HT1A, 5-HT2A and 5-HT3 receptors (R). There was a decreased (P<0.001) number of 5-HT1AR positive cells, the majority being tryptase positive, in involved and noninvolved psoriatic papillary dermis, compared to normal skin. 5-HTlAR expression was also found in the upper part of the epidermis, on vessel walls and on melanocytes. 5-HT2AR expressing papillary mononuclear cells, CD3 positive, were increased (P<0.001 and P<0.01, respectively) in involved and noninvolved psoriatic skin, compared to normal skin, an increase (P<0.01) also being found in the involved compared to noninvolved skin. Expression of 5-HT3R could be found in the basal epidermal layer of noninvolved but not in the involved skin of psoriasis, where it was only found in the acrosyringium. The present findings are compatible with the 5-HT1A and 5-HT2A receptors having antagonistic functions, and raise the possibility of using receptor specific drugs in the treatment of psoriasis.
KW - Psoriasis
KW - Receptors
KW - Serotonin
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U2 - 10.1007/s00403-006-0652-6
DO - 10.1007/s00403-006-0652-6
M3 - Article
C2 - 16794822
AN - SCOPUS:33748424565
SN - 0340-3696
VL - 298
SP - 99
EP - 106
JO - Archives of Dermatological Research
JF - Archives of Dermatological Research
IS - 3
ER -