Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia

Matthew T. Witkowski, Igor Dolgalev, Nikki A. Evensen, Chao Ma, Tiffany Chambers, Kathryn G. Roberts, Sheetal Sreeram, Yuling Dai, Anastasia N. Tikhonova, Audrey Lasry, Chunxu Qu, Deqing Pei, Cheng Cheng, Gabriel A. Robbins, Joanna Pierro, Shanmugapriya Selvaraj, Valeria Mezzano, Marla Daves, Philip J. Lupo, Michael E. ScheurerCynthia A. Loomis, Charles G. Mullighan, Weiqiang Chen, Karen R. Rabin, Aristotelis Tsirigos, William L. Carroll, Iannis Aifantis

Research output: Contribution to journalArticle

Abstract

Using single-cell analysis of B cell acute lymphoblastic leukemia (B-ALL) patient samples, Witkowski et al. show that the frequency of non-classical monocytes predicts patient survival. Depletion of these monocytes improves treatment responsiveness in animal models of high-risk B-ALL.

Original languageEnglish (US)
Pages (from-to)867-882.e12
JournalCancer Cell
Volume37
Issue number6
DOIs
StatePublished - Jun 8 2020

Keywords

  • acute lymphoblastic leukemia
  • chemotherapy
  • immune microenvironment
  • monocytes
  • relapse
  • single cell

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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  • Cite this

    Witkowski, M. T., Dolgalev, I., Evensen, N. A., Ma, C., Chambers, T., Roberts, K. G., Sreeram, S., Dai, Y., Tikhonova, A. N., Lasry, A., Qu, C., Pei, D., Cheng, C., Robbins, G. A., Pierro, J., Selvaraj, S., Mezzano, V., Daves, M., Lupo, P. J., ... Aifantis, I. (2020). Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia. Cancer Cell, 37(6), 867-882.e12. https://doi.org/10.1016/j.ccell.2020.04.015