Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia

Matthew T. Witkowski; Igor Dolgalev; Nikki A. Evensen; Chao Ma; Tiffany Chambers; Kathryn G. Roberts; Sheetal Sreeram; Yuling Dai; Anastasia N. Tikhonova; Audrey Lasry; Chunxu Qu; Deqing Pei; Cheng Cheng; Gabriel A. Robbins; Joanna Pierro; Shanmugapriya Selvaraj; Valeria Mezzano; Marla Daves; Philip J. Lupo; Michael E. Scheurer; Cynthia A. Loomis; Charles G. Mullighan; Weiqiang Chen; Karen R. Rabin; Aristotelis Tsirigos; William L. Carroll; Iannis Aifantis

doi:10.1016/j.ccell.2020.04.015

Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia

Matthew T. Witkowski, Igor Dolgalev, Nikki A. Evensen, Chao Ma, Tiffany Chambers, Kathryn G. Roberts, Sheetal Sreeram, Yuling Dai, Anastasia N. Tikhonova, Audrey Lasry, Chunxu Qu, Deqing Pei, Cheng Cheng, Gabriel A. Robbins, Joanna Pierro, Shanmugapriya Selvaraj, Valeria Mezzano, Marla Daves, Philip J. Lupo, Michael E. ScheurerCynthia A. Loomis, Charles G. Mullighan, Weiqiang Chen, Karen R. Rabin, Aristotelis Tsirigos, William L. Carroll, Iannis Aifantis

Mechanical and Aerospace Engineering

Research output: Contribution to journal › Article

Abstract

Using single-cell analysis of B cell acute lymphoblastic leukemia (B-ALL) patient samples, Witkowski et al. show that the frequency of non-classical monocytes predicts patient survival. Depletion of these monocytes improves treatment responsiveness in animal models of high-risk B-ALL.

Original language	English (US)
Pages (from-to)	867-882.e12
Journal	Cancer Cell
Volume	37
Issue number	6
DOIs	https://doi.org/10.1016/j.ccell.2020.04.015
State	Published - Jun 8 2020

Keywords

acute lymphoblastic leukemia
chemotherapy
immune microenvironment
monocytes
relapse
single cell

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

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Witkowski, M. T., Dolgalev, I., Evensen, N. A., Ma, C., Chambers, T., Roberts, K. G., Sreeram, S., Dai, Y., Tikhonova, A. N., Lasry, A., Qu, C., Pei, D., Cheng, C., Robbins, G. A., Pierro, J., Selvaraj, S., Mezzano, V., Daves, M., Lupo, P. J., ... Aifantis, I. (2020). Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia. Cancer Cell, 37(6), 867-882.e12. https://doi.org/10.1016/j.ccell.2020.04.015

Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia. / Witkowski, Matthew T.; Dolgalev, Igor; Evensen, Nikki A.; Ma, Chao; Chambers, Tiffany; Roberts, Kathryn G.; Sreeram, Sheetal; Dai, Yuling; Tikhonova, Anastasia N.; Lasry, Audrey; Qu, Chunxu; Pei, Deqing; Cheng, Cheng; Robbins, Gabriel A.; Pierro, Joanna; Selvaraj, Shanmugapriya; Mezzano, Valeria; Daves, Marla; Lupo, Philip J.; Scheurer, Michael E.; Loomis, Cynthia A.; Mullighan, Charles G.; Chen, Weiqiang; Rabin, Karen R.; Tsirigos, Aristotelis; Carroll, William L.; Aifantis, Iannis.

In: Cancer Cell, Vol. 37, No. 6, 08.06.2020, p. 867-882.e12.

Research output: Contribution to journal › Article

Witkowski, MT, Dolgalev, I, Evensen, NA, Ma, C, Chambers, T, Roberts, KG, Sreeram, S, Dai, Y, Tikhonova, AN, Lasry, A, Qu, C, Pei, D, Cheng, C, Robbins, GA, Pierro, J, Selvaraj, S, Mezzano, V, Daves, M, Lupo, PJ, Scheurer, ME, Loomis, CA, Mullighan, CG, Chen, W, Rabin, KR, Tsirigos, A, Carroll, WL & Aifantis, I 2020, 'Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia', Cancer Cell, vol. 37, no. 6, pp. 867-882.e12. https://doi.org/10.1016/j.ccell.2020.04.015

Witkowski, Matthew T. ; Dolgalev, Igor ; Evensen, Nikki A. ; Ma, Chao ; Chambers, Tiffany ; Roberts, Kathryn G. ; Sreeram, Sheetal ; Dai, Yuling ; Tikhonova, Anastasia N. ; Lasry, Audrey ; Qu, Chunxu ; Pei, Deqing ; Cheng, Cheng ; Robbins, Gabriel A. ; Pierro, Joanna ; Selvaraj, Shanmugapriya ; Mezzano, Valeria ; Daves, Marla ; Lupo, Philip J. ; Scheurer, Michael E. ; Loomis, Cynthia A. ; Mullighan, Charles G. ; Chen, Weiqiang ; Rabin, Karen R. ; Tsirigos, Aristotelis ; Carroll, William L. ; Aifantis, Iannis. / Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia. In: Cancer Cell. 2020 ; Vol. 37, No. 6. pp. 867-882.e12.

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abstract = "Using single-cell analysis of B cell acute lymphoblastic leukemia (B-ALL) patient samples, Witkowski et al. show that the frequency of non-classical monocytes predicts patient survival. Depletion of these monocytes improves treatment responsiveness in animal models of high-risk B-ALL.",

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AU - Roberts, Kathryn G.

AU - Sreeram, Sheetal

AU - Dai, Yuling

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AU - Qu, Chunxu

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AU - Daves, Marla

AU - Lupo, Philip J.

AU - Scheurer, Michael E.

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AU - Mullighan, Charles G.

AU - Chen, Weiqiang

AU - Rabin, Karen R.

AU - Tsirigos, Aristotelis

AU - Carroll, William L.

AU - Aifantis, Iannis

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