Eye position-dependent opsoclonus in mild traumatic brain injury

John Ross Rizzo; Todd E. Hudson; Alexandra J. Sequeira; Weiwei Dai; Yash Chaudhry; John Martone; David S. Zee; Lance M. Optican; Laura J. Balcer; Steven L. Galetta; Janet C. Rucker

doi:10.1016/bs.pbr.2019.04.016

Eye position-dependent opsoclonus in mild traumatic brain injury

John Ross Rizzo, Todd E. Hudson, Alexandra J. Sequeira, Weiwei Dai, Yash Chaudhry, John Martone, David S. Zee, Lance M. Optican, Laura J. Balcer, Steven L. Galetta, Janet C. Rucker

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Opsoclonus consists of bursts of involuntary, multidirectional, back-to-back saccades without an intersaccadic interval. We report a 60-year-old man with post-concussive headaches and disequilibrium who had small amplitude opsoclonus in left gaze, along with larger amplitude flutter during convergence. Examination was otherwise normal and brain MRI was unremarkable. Video-oculography demonstrated opsoclonus predominantly in left gaze and during pursuit in the left hemifield, which improved as post-concussive symptoms improved. Existing theories of opsoclonus mechanisms do not account for this eye position-dependence. We discuss theoretical mechanisms of this behavior, including possible dysfunction of frontal eye field and/or cerebellar vermis neurons; review ocular oscillations in traumatic brain injury; and consider the potential relationship between the larger amplitude flutter upon convergence and post-traumatic ocular oscillations.

Original language	English (US)
Title of host publication	Mathematical Modelling in Motor Neuroscience
Subtitle of host publication	State of the Art and Translation to the Clinic. Gaze Orienting Mechanisms and Disease
Editors	Stefano Ramat, Aasef G. Shaikh
Publisher	Elsevier B.V.
Pages	65-78
Number of pages	14
Volume	249
ISBN (Print)	9780444642547
DOIs	https://doi.org/10.1016/bs.pbr.2019.04.016
State	Published - 2019

Publication series

Name	Progress in brain research
ISSN (Print)	0079-6123

Keywords

Concussion
Eye position-dependence
Ocular flutter
Opsoclonus
Saccades
Fixation, Ocular/physiology
Ocular Motility Disorders/etiology
Humans
Middle Aged
Brain Concussion/complications
Male
Eye Movement Measurements
Saccades/physiology

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/bs.pbr.2019.04.016

Cite this

Rizzo, J. R., Hudson, T. E., Sequeira, A. J., Dai, W., Chaudhry, Y., Martone, J., Zee, D. S., Optican, L. M., Balcer, L. J., Galetta, S. L., & Rucker, J. C. (2019). Eye position-dependent opsoclonus in mild traumatic brain injury. In S. Ramat, & A. G. Shaikh (Eds.), Mathematical Modelling in Motor Neuroscience: State of the Art and Translation to the Clinic. Gaze Orienting Mechanisms and Disease (Vol. 249, pp. 65-78). (Progress in brain research). Elsevier B.V.. https://doi.org/10.1016/bs.pbr.2019.04.016

Eye position-dependent opsoclonus in mild traumatic brain injury. / Rizzo, John Ross; Hudson, Todd E.; Sequeira, Alexandra J. et al.
Mathematical Modelling in Motor Neuroscience: State of the Art and Translation to the Clinic. Gaze Orienting Mechanisms and Disease. ed. / Stefano Ramat; Aasef G. Shaikh. Vol. 249 Elsevier B.V., 2019. p. 65-78 (Progress in brain research).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Rizzo, JR, Hudson, TE, Sequeira, AJ, Dai, W, Chaudhry, Y, Martone, J, Zee, DS, Optican, LM, Balcer, LJ, Galetta, SL & Rucker, JC 2019, Eye position-dependent opsoclonus in mild traumatic brain injury. in S Ramat & AG Shaikh (eds), Mathematical Modelling in Motor Neuroscience: State of the Art and Translation to the Clinic. Gaze Orienting Mechanisms and Disease. vol. 249, Progress in brain research, Elsevier B.V., pp. 65-78. https://doi.org/10.1016/bs.pbr.2019.04.016

Rizzo JR, Hudson TE, Sequeira AJ, Dai W, Chaudhry Y, Martone J et al. Eye position-dependent opsoclonus in mild traumatic brain injury. In Ramat S, Shaikh AG, editors, Mathematical Modelling in Motor Neuroscience: State of the Art and Translation to the Clinic. Gaze Orienting Mechanisms and Disease. Vol. 249. Elsevier B.V. 2019. p. 65-78. (Progress in brain research). doi: 10.1016/bs.pbr.2019.04.016

Rizzo, John Ross ; Hudson, Todd E. ; Sequeira, Alexandra J. et al. / Eye position-dependent opsoclonus in mild traumatic brain injury. Mathematical Modelling in Motor Neuroscience: State of the Art and Translation to the Clinic. Gaze Orienting Mechanisms and Disease. editor / Stefano Ramat ; Aasef G. Shaikh. Vol. 249 Elsevier B.V., 2019. pp. 65-78 (Progress in brain research).

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Eye position-dependent opsoclonus in mild traumatic brain injury

Abstract

Publication series

Keywords

ASJC Scopus subject areas

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