Eye position-dependent opsoclonus in mild traumatic brain injury

John Ross Rizzo, Todd E. Hudson, Alexandra J. Sequeira, Weiwei Dai, Yash Chaudhry, John Martone, David S. Zee, Lance M. Optican, Laura J. Balcer, Steven L. Galetta, Janet C. Rucker

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Opsoclonus consists of bursts of involuntary, multidirectional, back-to-back saccades without an intersaccadic interval. We report a 60-year-old man with post-concussive headaches and disequilibrium who had small amplitude opsoclonus in left gaze, along with larger amplitude flutter during convergence. Examination was otherwise normal and brain MRI was unremarkable. Video-oculography demonstrated opsoclonus predominantly in left gaze and during pursuit in the left hemifield, which improved as post-concussive symptoms improved. Existing theories of opsoclonus mechanisms do not account for this eye position-dependence. We discuss theoretical mechanisms of this behavior, including possible dysfunction of frontal eye field and/or cerebellar vermis neurons; review ocular oscillations in traumatic brain injury; and consider the potential relationship between the larger amplitude flutter upon convergence and post-traumatic ocular oscillations.

    Original languageEnglish (US)
    Title of host publicationProgress in Brain Research
    EditorsStefano Ramat, Aasef G. Shaikh
    PublisherElsevier B.V.
    Pages65-78
    Number of pages14
    ISBN (Print)9780444642547
    DOIs
    StatePublished - 2019

    Publication series

    NameProgress in Brain Research
    Volume249
    ISSN (Print)0079-6123
    ISSN (Electronic)1875-7855

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    Keywords

    • Concussion
    • Eye position-dependence
    • Ocular flutter
    • Opsoclonus
    • Saccades

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Rizzo, J. R., Hudson, T. E., Sequeira, A. J., Dai, W., Chaudhry, Y., Martone, J., Zee, D. S., Optican, L. M., Balcer, L. J., Galetta, S. L., & Rucker, J. C. (2019). Eye position-dependent opsoclonus in mild traumatic brain injury. In S. Ramat, & A. G. Shaikh (Eds.), Progress in Brain Research (pp. 65-78). (Progress in Brain Research; Vol. 249). Elsevier B.V.. https://doi.org/10.1016/bs.pbr.2019.04.016