Facilitated sexual behavior reversed and serotonin restored by raphe nuclei transplanted into denervated hypothalamus

Victoria N. Luine; Kenneth J. Renner; Maya Frankfurt; Efrain C. Azmitia

doi:10.1126/science.6209800

Facilitated sexual behavior reversed and serotonin restored by raphe nuclei transplanted into denervated hypothalamus

Victoria N. Luine, Kenneth J. Renner, Maya Frankfurt, Efrain C. Azmitia

Biology and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

Fetal raphe cells transplanted into the hypothalamus reversed facilitation of feminine sexual behavior in rats with brain lesions induced by 5,7-dihydroxytryptamine. Immunocytochemical and chemical analyses of serotonin indicate that reinnervation of the ventromedial nucleus of the hypothalamus by the transplants is associated with behavioral recovery. The findings suggest that transplanted fetal tissue can exert functional regulation over an innate, complex, hormone-dependent behavior in adult rats.

Original language	English (US)
Pages (from-to)	1436-1439
Number of pages	4
Journal	Science
Volume	226
Issue number	4681
DOIs	https://doi.org/10.1126/science.6209800
State	Published - 1984

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title = "Facilitated sexual behavior reversed and serotonin restored by raphe nuclei transplanted into denervated hypothalamus",

abstract = "Fetal raphe cells transplanted into the hypothalamus reversed facilitation of feminine sexual behavior in rats with brain lesions induced by 5,7-dihydroxytryptamine. Immunocytochemical and chemical analyses of serotonin indicate that reinnervation of the ventromedial nucleus of the hypothalamus by the transplants is associated with behavioral recovery. The findings suggest that transplanted fetal tissue can exert functional regulation over an innate, complex, hormone-dependent behavior in adult rats.",

author = "Luine, {Victoria N.} and Renner, {Kenneth J.} and Maya Frankfurt and Azmitia, {Efrain C.}",

year = "1984",

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AU - Luine, Victoria N.

AU - Renner, Kenneth J.

AU - Frankfurt, Maya

AU - Azmitia, Efrain C.

PY - 1984

Y1 - 1984

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AB - Fetal raphe cells transplanted into the hypothalamus reversed facilitation of feminine sexual behavior in rats with brain lesions induced by 5,7-dihydroxytryptamine. Immunocytochemical and chemical analyses of serotonin indicate that reinnervation of the ventromedial nucleus of the hypothalamus by the transplants is associated with behavioral recovery. The findings suggest that transplanted fetal tissue can exert functional regulation over an innate, complex, hormone-dependent behavior in adult rats.

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Facilitated sexual behavior reversed and serotonin restored by raphe nuclei transplanted into denervated hypothalamus

Abstract

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