Facilitated sexual behavior reversed and serotonin restored by raphe nuclei transplanted into denervated hypothalamus

Victoria N. Luine, Kenneth J. Renner, Maya Frankfurt, Efrain C. Azmitia

Research output: Contribution to journalArticle

Abstract

Fetal raphe cells transplanted into the hypothalamus reversed facilitation of feminine sexual behavior in rats with brain lesions induced by 5,7-dihydroxytryptamine. Immunocytochemical and chemical analyses of serotonin indicate that reinnervation of the ventromedial nucleus of the hypothalamus by the transplants is associated with behavioral recovery. The findings suggest that transplanted fetal tissue can exert functional regulation over an innate, complex, hormone-dependent behavior in adult rats.

Original languageEnglish (US)
Pages (from-to)1436-1439
Number of pages4
JournalScience
Volume226
Issue number4681
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • General

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