Family income, parental education and brain structure in children and adolescents

Kimberly G. Noble, Suzanne M. Houston, Natalie H. Brito, Hauke Bartsch, Eric Kan, Joshua M. Kuperman, Natacha Akshoomoff, David G. Amaral, Cinnamon S. Bloss, Ondrej Libiger, Nicholas J. Schork, Sarah S. Murray, B. J. Casey, Linda Chang, Thomas M. Ernst, Jean A. Frazier, Jeffrey R. Gruen, David N. Kennedy, Peter Van Zijl, Stewart MostofskyWalter E. Kaufmann, Tal Kenet, Anders M. Dale, Terry L. Jernigan, Elizabeth R. Sowell

Research output: Contribution to journalArticle

Abstract

Socioeconomic disparities are associated with differences in cognitive development. The extent to which this translates to disparities in brain structure is unclear. We investigated relationships between socioeconomic factors and brain morphometry, independently of genetic ancestry, among a cohort of 1,099 typically developing individuals between 3 and 20 years of age. Income was logarithmically associated with brain surface area. Among children from lower income families, small differences in income were associated with relatively large differences in surface area, whereas, among children from higher income families, similar income increments were associated with smaller differences in surface area. These relationships were most prominent in regions supporting language, reading, executive functions and spatial skills; surface area mediated socioeconomic differences in certain neurocognitive abilities. These data imply that income relates most strongly to brain structure among the most disadvantaged children.

Original languageEnglish (US)
Pages (from-to)773-778
Number of pages6
JournalNature Neuroscience
Volume18
Issue number5
DOIs
StatePublished - Apr 28 2015

ASJC Scopus subject areas

  • Neuroscience(all)

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