TY - JOUR
T1 - Fast and Sensitive Detection of Paramagnetic Species Using Coupled Charge and Spin Dynamics in Strongly Fluorescent Nanodiamonds
AU - Gorrini, F.
AU - Giri, R.
AU - Avalos, C. E.
AU - Tambalo, S.
AU - Mannucci, S.
AU - Basso, L.
AU - Bazzanella, N.
AU - Dorigoni, C.
AU - Cazzanelli, M.
AU - Marzola, P.
AU - Miotello, A.
AU - Bifone, A.
N1 - Publisher Copyright:
© 2019 American Chemical Society.
PY - 2019/7/10
Y1 - 2019/7/10
N2 - Sensing of a few unpaired electron spins, such as in metal ions and radicals, is a useful but difficult task in nanoscale physics, biology, and chemistry. Single negatively charged nitrogen-vacancy (NV-) centers in diamond offer high sensitivity and spatial resolution in the optical detection of weak magnetic fields produced by a spin bath but often require long acquisition times on the order of seconds. Here, we present an approach based on coupled spin and charge dynamics in dense NV ensembles in strongly fluorescent nanodiamonds (NDs) to sense external magnetic dipoles. We apply this approach to various paramagnetic species, including gadolinium complexes, magnetite nanoparticles, and hemoglobin in whole blood. Taking advantage of the high NV density, we demonstrate a dramatic reduction in acquisition time (down to tens of milliseconds) while maintaining high sensitivity to paramagnetic centers. Strong luminescence, high sensitivity, and short acquisition time make dense NV- ensembles in NDs a potentially promising tool for biosensing and bioimaging applications.
AB - Sensing of a few unpaired electron spins, such as in metal ions and radicals, is a useful but difficult task in nanoscale physics, biology, and chemistry. Single negatively charged nitrogen-vacancy (NV-) centers in diamond offer high sensitivity and spatial resolution in the optical detection of weak magnetic fields produced by a spin bath but often require long acquisition times on the order of seconds. Here, we present an approach based on coupled spin and charge dynamics in dense NV ensembles in strongly fluorescent nanodiamonds (NDs) to sense external magnetic dipoles. We apply this approach to various paramagnetic species, including gadolinium complexes, magnetite nanoparticles, and hemoglobin in whole blood. Taking advantage of the high NV density, we demonstrate a dramatic reduction in acquisition time (down to tens of milliseconds) while maintaining high sensitivity to paramagnetic centers. Strong luminescence, high sensitivity, and short acquisition time make dense NV- ensembles in NDs a potentially promising tool for biosensing and bioimaging applications.
KW - charge dynamics
KW - nanodiamonds
KW - nitrogen-vacancy centers
KW - spin relaxation
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U2 - 10.1021/acsami.9b05779
DO - 10.1021/acsami.9b05779
M3 - Article
C2 - 31199615
AN - SCOPUS:85069626112
SN - 1944-8244
VL - 11
SP - 24412
EP - 24422
JO - ACS applied materials & interfaces
JF - ACS applied materials & interfaces
IS - 27
ER -