A fast tree-search algorithm was used to find the ground states of all sequences for a 4X3X3 lattice HP model of proteins. The results confirm the existence of highly designable structures in a three-dimensional solvation model with a surface-to-core ratio of 2- to-1, close to the values for small natural proteins. Highly designable structures were found to differ geometrically from other structures.
ASJC Scopus subject areas
- Physics and Astronomy(all)
- Physical and Theoretical Chemistry