Abstract
Kinetics of voltage-gated ionic channels fundamentally reflect the response of the channels to local electric fields. In this report cell- attached patch-clamp studies reveal that the voltage-dependent activation rate of sodium channels residing in the growth cone membrane differs from that of soma sodium channels in differentiating N1E-115 neuroblastoma cells. Because other electrophysiological properties of these channels do not differ, this finding may be a reflection of the difference in intramembrane electric field in these two regions of the cell. This represents a new mechanism for channels to attain a range of activities both within and between cells.
Original language | English (US) |
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Pages (from-to) | 2501-2508 |
Number of pages | 8 |
Journal | Biophysical journal |
Volume | 71 |
Issue number | 5 |
DOIs | |
State | Published - Nov 1996 |
ASJC Scopus subject areas
- Biophysics