TY - JOUR
T1 - Fatigue levels and associated factors in systemic sclerosis
T2 - a cross-sectional study of 2385 SPIN Cohort participants
AU - on behalf of the Scleroderma Patient-centered Intervention Network Investigators
AU - Kwakkenbos, Linda
AU - Levis, Brooke
AU - Henry, Richard S.
AU - Virgili-Gervais, Gabrielle
AU - Carrier, Marie Eve
AU - Bartlett, Susan J.
AU - Gietzen, Amy
AU - Gottesman, Karen
AU - Guillot, Genevieve
AU - Lawrie-Jones, Amanda
AU - Hummers, Laura K.
AU - Malcarne, Vanessa L.
AU - Mayes, Maureen D.
AU - Richard, Michelle
AU - Wojeck, Robyn K.
AU - Worron-Sauvé, Maureen
AU - Hudson, Marie
AU - Mouthon, Luc
AU - Benedetti, Andrea
AU - Thombs, Brett D.
AU - Adams, Claire E.
AU - El-Baalbaki, Ghassan
AU - Fligelstone, Kim
AU - Frech, Tracy
AU - Harel, Daphna
AU - Hinchcliff, Monique
AU - Johnson, Sindhu R.
AU - Larche, Maggie
AU - Leite, Catarina
AU - Nguyen, Christelle
AU - Nielsen, Karen
AU - Pope, Janet
AU - Rannou, François
AU - Rodriguez-Reyna, Tatiana Sofia
AU - Schouffoer, Anne A.
AU - Suarez-Almazor, Maria E.
AU - Agard, Christian
AU - Alric, Laurent
AU - André, Marc
AU - Beaslay, Floryan
AU - Bernstein, Elana J.
AU - Berthier, Sabine
AU - Bissonnette, Lyne
AU - Blaise, Sophie
AU - Bories, Eva
AU - Bruns, Alessandra
AU - Cacciatore, Carlotta
AU - Carreira, Patricia
AU - Casadevall, Marion
AU - Chaigne, Benjamin
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2025/5/1
Y1 - 2025/5/1
N2 - Objectives: The objectives of this study were to compare fatigue in a large multinational SSc cohort with general population data and identify associated sociodemographic, lifestyle and SSc disease factors. Methods: Scleroderma Patient-centered Intervention Network Cohort participants completed the Patient-Reported Outcomes Measurement Information System-29 v2.0 fatigue domain. T-scores were compared with the USA general population (mean¼50; S.D.¼10). Multivariable linear regression was used to assess associations with sociodemographic, lifestyle, and disease-related variables. Results: Among the 2385 participants [mean age 54.9 (S.D.¼12.6) years, 87% female, 38% dcSSc], the mean fatigue T-score was 54.6 (S.D.¼11.0); 438 (18%) reported mild fatigue, 641 (27%) moderate fatigue, and 180 (8%) severe fatigue. Fatigue was independently associated with sociodemographic factors age [−0.10 points per year, (95% CI −0.14, −0.07)], male sex [−1.67 points, (−2.96, −0.37)], non-married status [0.97 points (0.04, 1.89)] and country [reference USA; France −2.35 points (−3.48, −1.21) and UK 2.38 points (0.80, 3.97)], and lifestyle factors smoking [4.16 points (2.52, 5.80)], alcohol consumption [−0.18 points per drink per week (−0.28, −0.07)] and BMI [0.34 points per unit (0.27, 0.42)]. Fatigue was associated with disease-related factors, including gastrointestinal involvement [4.21 points (2.99, 5.43)], digital ulcers [1.51 points, (0.25, 2.77)], moderate small joint contractures (1.41 points [0.13, 2.69]), RA [4.34 points (2.37, 6.31)] and SS [1.89 points (0.23, 3.55)]. When pain was included in the model, its association was large [2.19 points (2.03, 2.34)], and interstitial lung disease was also associated [1.21 points (0.42, 2.00)]. Conclusion: In people with SSc, fatigue scores were substantially higher than in the general population and associated with multiple disease factors, including gastrointestinal involvement, several painful disease manifestations, and lung involvement.
AB - Objectives: The objectives of this study were to compare fatigue in a large multinational SSc cohort with general population data and identify associated sociodemographic, lifestyle and SSc disease factors. Methods: Scleroderma Patient-centered Intervention Network Cohort participants completed the Patient-Reported Outcomes Measurement Information System-29 v2.0 fatigue domain. T-scores were compared with the USA general population (mean¼50; S.D.¼10). Multivariable linear regression was used to assess associations with sociodemographic, lifestyle, and disease-related variables. Results: Among the 2385 participants [mean age 54.9 (S.D.¼12.6) years, 87% female, 38% dcSSc], the mean fatigue T-score was 54.6 (S.D.¼11.0); 438 (18%) reported mild fatigue, 641 (27%) moderate fatigue, and 180 (8%) severe fatigue. Fatigue was independently associated with sociodemographic factors age [−0.10 points per year, (95% CI −0.14, −0.07)], male sex [−1.67 points, (−2.96, −0.37)], non-married status [0.97 points (0.04, 1.89)] and country [reference USA; France −2.35 points (−3.48, −1.21) and UK 2.38 points (0.80, 3.97)], and lifestyle factors smoking [4.16 points (2.52, 5.80)], alcohol consumption [−0.18 points per drink per week (−0.28, −0.07)] and BMI [0.34 points per unit (0.27, 0.42)]. Fatigue was associated with disease-related factors, including gastrointestinal involvement [4.21 points (2.99, 5.43)], digital ulcers [1.51 points, (0.25, 2.77)], moderate small joint contractures (1.41 points [0.13, 2.69]), RA [4.34 points (2.37, 6.31)] and SS [1.89 points (0.23, 3.55)]. When pain was included in the model, its association was large [2.19 points (2.03, 2.34)], and interstitial lung disease was also associated [1.21 points (0.42, 2.00)]. Conclusion: In people with SSc, fatigue scores were substantially higher than in the general population and associated with multiple disease factors, including gastrointestinal involvement, several painful disease manifestations, and lung involvement.
KW - fatigue
KW - patient-centred care
KW - patient-reported outcome measures
KW - scleroderma
KW - systemic
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U2 - 10.1093/rheumatology/keae570
DO - 10.1093/rheumatology/keae570
M3 - Article
C2 - 39447026
AN - SCOPUS:105004699891
SN - 1462-0324
VL - 64
SP - 2810
EP - 2820
JO - Rheumatology
JF - Rheumatology
IS - 5
ER -