Fear memory formation involves p190 RhoGAP and ROCK proteins through a GRB2-mediated complex

Raphael Lamprecht, Claudia R. Farb, Joseph E. LeDoux

Research output: Contribution to journalArticle

Abstract

We used fear conditioning, which is known to alter synaptic efficacy in lateral amygdala (LA), to study molecular mechanisms underlying long-term memory. Following fear conditioning, the tyrosine phosphorylated protein p190 RhoGAP becomes associated with GRB2 in LA significantly more in conditioned than in control rats. RasGAP and Shc were also found to associate with GRB2 in LA significantly more in the conditioned animals. Inhibition of the p190 RhoGAP-downstream kinase ROCK in LA during fear conditioning impaired long- but not short-term memory. Thus, the p190 RhoGAP/ROCK pathway, which regulates the morphology of dendrites and axons during neural development, plays a central role, through a GRB2-mediated molecular complex, in fear memory formation in the lateral amygdala.

Original languageEnglish (US)
Pages (from-to)727-738
Number of pages12
JournalNeuron
Volume36
Issue number4
DOIs
StatePublished - Nov 14 2002

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Fear memory formation involves p190 RhoGAP and ROCK proteins through a GRB2-mediated complex'. Together they form a unique fingerprint.

  • Cite this