Fear-related activity in subgenual anterior cingulate differs between men and women

Tracy Butler; Hong Pan; Jane Epstein; Xenia Protopopescu; Oliver Tuescher; Martin Goldstein; Marylene Cloitre; Yihong Yang; Elizabeth Phelps; Jack Gorman; Joseph Ledoux; Emily Stern; David Silbersweig

doi:10.1097/00001756-200508010-00020

Fear-related activity in subgenual anterior cingulate differs between men and women

Tracy Butler, Hong Pan, Jane Epstein, Xenia Protopopescu, Oliver Tuescher, Martin Goldstein, Marylene Cloitre, Yihong Yang, Elizabeth Phelps, Jack Gorman, Joseph Ledoux, Emily Stern, David Silbersweig

Research output: Contribution to journal › Article › peer-review

Abstract

Functional magnetic resonance imaging in association with an instructed fear/anticipatory anxiety paradigm was used to explore sex differences in the human fear response. During anticipation of mild electrodermal stimulation, women, as compared with men, demonstrated increased activity in the subgenual anterior cingulate cortex and functionally related regions of the insula and brainstem. The subgenual anterior cingulate cortex is a region critical for emotional control implicated in the pathogenesis of psychiatric disease. Present findings suggest a contributory neural substrate for the greater susceptibility of women to anxiety and affective disorders, and emphasize the importance of considering participant sex when designing and interpreting functional neuroimaging studies.

Original language	English (US)
Pages (from-to)	1233-1236
Number of pages	4
Journal	NeuroReport
Volume	16
Issue number	11
DOIs	https://doi.org/10.1097/00001756-200508010-00020
State	Published - Aug 1 2005

Keywords

Anticipatory anxiety
Emotion
Functional magnetic resonance imaging
Instructed fear
Sex
Sex differences
Ventromedial prefrontal cortex

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1097/00001756-200508010-00020

Cite this

@article{259b469335af466b91ef7ccba871e602,

title = "Fear-related activity in subgenual anterior cingulate differs between men and women",

abstract = "Functional magnetic resonance imaging in association with an instructed fear/anticipatory anxiety paradigm was used to explore sex differences in the human fear response. During anticipation of mild electrodermal stimulation, women, as compared with men, demonstrated increased activity in the subgenual anterior cingulate cortex and functionally related regions of the insula and brainstem. The subgenual anterior cingulate cortex is a region critical for emotional control implicated in the pathogenesis of psychiatric disease. Present findings suggest a contributory neural substrate for the greater susceptibility of women to anxiety and affective disorders, and emphasize the importance of considering participant sex when designing and interpreting functional neuroimaging studies.",

keywords = "Anticipatory anxiety, Emotion, Functional magnetic resonance imaging, Instructed fear, Sex, Sex differences, Ventromedial prefrontal cortex",

author = "Tracy Butler and Hong Pan and Jane Epstein and Xenia Protopopescu and Oliver Tuescher and Martin Goldstein and Marylene Cloitre and Yihong Yang and Elizabeth Phelps and Jack Gorman and Joseph Ledoux and Emily Stern and David Silbersweig",

year = "2005",

month = aug,

day = "1",

doi = "10.1097/00001756-200508010-00020",

language = "English (US)",

volume = "16",

pages = "1233--1236",

journal = "NeuroReport",

issn = "0959-4965",

publisher = "Lippincott Williams and Wilkins",

number = "11",

}

TY - JOUR

T1 - Fear-related activity in subgenual anterior cingulate differs between men and women

AU - Butler, Tracy

AU - Pan, Hong

AU - Epstein, Jane

AU - Protopopescu, Xenia

AU - Tuescher, Oliver

AU - Goldstein, Martin

AU - Cloitre, Marylene

AU - Yang, Yihong

AU - Phelps, Elizabeth

AU - Gorman, Jack

AU - Ledoux, Joseph

AU - Stern, Emily

AU - Silbersweig, David

PY - 2005/8/1

Y1 - 2005/8/1

N2 - Functional magnetic resonance imaging in association with an instructed fear/anticipatory anxiety paradigm was used to explore sex differences in the human fear response. During anticipation of mild electrodermal stimulation, women, as compared with men, demonstrated increased activity in the subgenual anterior cingulate cortex and functionally related regions of the insula and brainstem. The subgenual anterior cingulate cortex is a region critical for emotional control implicated in the pathogenesis of psychiatric disease. Present findings suggest a contributory neural substrate for the greater susceptibility of women to anxiety and affective disorders, and emphasize the importance of considering participant sex when designing and interpreting functional neuroimaging studies.

AB - Functional magnetic resonance imaging in association with an instructed fear/anticipatory anxiety paradigm was used to explore sex differences in the human fear response. During anticipation of mild electrodermal stimulation, women, as compared with men, demonstrated increased activity in the subgenual anterior cingulate cortex and functionally related regions of the insula and brainstem. The subgenual anterior cingulate cortex is a region critical for emotional control implicated in the pathogenesis of psychiatric disease. Present findings suggest a contributory neural substrate for the greater susceptibility of women to anxiety and affective disorders, and emphasize the importance of considering participant sex when designing and interpreting functional neuroimaging studies.

KW - Anticipatory anxiety

KW - Emotion

KW - Functional magnetic resonance imaging

KW - Instructed fear

KW - Sex

KW - Sex differences

KW - Ventromedial prefrontal cortex

UR - http://www.scopus.com/inward/record.url?scp=23044499109&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23044499109&partnerID=8YFLogxK

U2 - 10.1097/00001756-200508010-00020

DO - 10.1097/00001756-200508010-00020

M3 - Article

C2 - 16012355

AN - SCOPUS:23044499109

SN - 0959-4965

VL - 16

SP - 1233

EP - 1236

JO - NeuroReport

JF - NeuroReport

IS - 11

ER -

Fear-related activity in subgenual anterior cingulate differs between men and women

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this