Fear-related activity in subgenual anterior cingulate differs between men and women

Tracy Butler, Hong Pan, Jane Epstein, Xenia Protopopescu, Oliver Tuescher, Martin Goldstein, Marylene Cloitre, Yihong Yang, Elizabeth Phelps, Jack Gorman, Joseph Ledoux, Emily Stern, David Silbersweig

Research output: Contribution to journalArticlepeer-review


Functional magnetic resonance imaging in association with an instructed fear/anticipatory anxiety paradigm was used to explore sex differences in the human fear response. During anticipation of mild electrodermal stimulation, women, as compared with men, demonstrated increased activity in the subgenual anterior cingulate cortex and functionally related regions of the insula and brainstem. The subgenual anterior cingulate cortex is a region critical for emotional control implicated in the pathogenesis of psychiatric disease. Present findings suggest a contributory neural substrate for the greater susceptibility of women to anxiety and affective disorders, and emphasize the importance of considering participant sex when designing and interpreting functional neuroimaging studies.

Original languageEnglish (US)
Pages (from-to)1233-1236
Number of pages4
Issue number11
StatePublished - Aug 1 2005


  • Anticipatory anxiety
  • Emotion
  • Functional magnetic resonance imaging
  • Instructed fear
  • Sex
  • Sex differences
  • Ventromedial prefrontal cortex

ASJC Scopus subject areas

  • General Neuroscience


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