Feasibility of Point-of-Care Urine Self-Testing to Measure Tenofovir Adherence and Predict Viral Suppression

Renata Buccheri, Matthew A. Spinelli, Megan J. Heise, David V. Glidden, Kevin Sassaman, Tyler Martinson, Hannah R. Schmidt, Alexa B. D'angelo, Dustin T. Duncan, Keith J. Horvath, Sabina Hirshfield, Renessa S. Williams, Mallory O. Johnson, Christian Grov, Adam Carrico, Monica Gandhi

Research output: Contribution to journalArticlepeer-review

Abstract

This study is the first to demonstrate the feasibility of at-home adherence monitoring using a point-of-care urine assay for tenofovir (TFV). Undetectable TFV is strongly associated with lower viral suppression (odds ratio, 0.19, 95% CI, 0.10-0.34; P <. 001), supporting a streamlined, effective approach for monitoring adherence between viral load assessments.

Original languageEnglish (US)
Article numberofaf300
JournalOpen Forum Infectious Diseases
Volume12
Issue number6
DOIs
StatePublished - Jun 1 2025

Keywords

  • adherence
  • antiretroviral therapy
  • point-of-care monitoring
  • tenofovir
  • viral suppression

ASJC Scopus subject areas

  • Oncology
  • Infectious Diseases

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