Fetal cleft lip repair in rabbits: Postnatal facial growth after repair

Thomas B. Dodson, Brian Schmidt, Michael T. Longaker, Leonard B. Kaban

Research output: Contribution to journalArticle

Abstract

We have previously described a model for in utero cleft lip repair in rabbits. Cleft lip and alveolus (CL) were created in fetal rabbits at 24 days gestation (term, 31 days). In this study, postnatal maxillary growth was evaluated in three groups of animals: 1) unoperated controls, 2) unrepaired CL, and 2) repaired CL. The animals were killed at 4, 12, and 26 weeks after birth. Direct cephalometry was performed on dry skulls to evaluate premaxillary width, anterior maxillary length and width, and posterior maxillary width. The results of this study indicate that rabbits that undergo an in utero CL procedure, with or without repair, exhibit no significant decrease in maxillary length and width when compared with controls.

Original languageEnglish (US)
Pages (from-to)603-611
Number of pages9
JournalJournal of Oral and Maxillofacial Surgery
Volume49
Issue number6
DOIs
StatePublished - Jun 1991

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

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