TY - JOUR
T1 - Fetal cleft lip repair in rabbits
T2 - Postnatal facial growth after repair
AU - Dodson, Thomas B.
AU - Schmidt, Brian
AU - Longaker, Michael T.
AU - Kaban, Leonard B.
N1 - Funding Information:
Received from the University of California San Francisco. * Adjunct Assistant Clinical Professor, Department of Oral and Maxillofacial Surgery. t Professor and Chairman. Denartment of Oral and Maxillofacial Surgery. $ Summer Research Fellow, Department of Oral and Maxillofacial Surgery. 8 Research Fellow, Department of Surgery and the Fetal Treatment Program. This work was supported by a Research Support Grant from the American Association of Oral and Maxillofacial Surgeons (LBK), a University of California San Francisco School of Dentistry Research Grant (LBK), NIH Grant R03 DE0 9325-01, and the Department of Oral and Maxillofacial Surgery Research Fund. Presented at the 72nd Annual Meeting of the American Association of Oral and Maxillofacial Surgeons, New Orleans, September 15, 1990. Address correspondence and reprint requests to Dr Kaban: Department of Oral and Maxillofacial Surgery, University of California San Francisco, 513 Pamassus Ave. San Francisco, CA 94143-0440.
PY - 1991/6
Y1 - 1991/6
N2 - We have previously described a model for in utero cleft lip repair in rabbits. Cleft lip and alveolus (CL) were created in fetal rabbits at 24 days gestation (term, 31 days). In this study, postnatal maxillary growth was evaluated in three groups of animals: 1) unoperated controls, 2) unrepaired CL, and 2) repaired CL. The animals were killed at 4, 12, and 26 weeks after birth. Direct cephalometry was performed on dry skulls to evaluate premaxillary width, anterior maxillary length and width, and posterior maxillary width. The results of this study indicate that rabbits that undergo an in utero CL procedure, with or without repair, exhibit no significant decrease in maxillary length and width when compared with controls.
AB - We have previously described a model for in utero cleft lip repair in rabbits. Cleft lip and alveolus (CL) were created in fetal rabbits at 24 days gestation (term, 31 days). In this study, postnatal maxillary growth was evaluated in three groups of animals: 1) unoperated controls, 2) unrepaired CL, and 2) repaired CL. The animals were killed at 4, 12, and 26 weeks after birth. Direct cephalometry was performed on dry skulls to evaluate premaxillary width, anterior maxillary length and width, and posterior maxillary width. The results of this study indicate that rabbits that undergo an in utero CL procedure, with or without repair, exhibit no significant decrease in maxillary length and width when compared with controls.
UR - http://www.scopus.com/inward/record.url?scp=0025811885&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025811885&partnerID=8YFLogxK
U2 - 10.1016/0278-2391(91)90342-J
DO - 10.1016/0278-2391(91)90342-J
M3 - Article
C2 - 2037916
AN - SCOPUS:0025811885
SN - 0278-2391
VL - 49
SP - 603
EP - 611
JO - Journal of Oral and Maxillofacial Surgery
JF - Journal of Oral and Maxillofacial Surgery
IS - 6
ER -