Fetal raphe neurons grafted into the hippocampus develop normal adult physiological properties

Manahem Segal, Efrain C. Azmitia

Research output: Contribution to journalArticlepeer-review

Abstract

Embryonic midbrain raphe was grafted into serotonin-deficient adult rat hippocampus. Serotonin-containing neurons in the graft survive for at least 6 months after grafting. Grafted neurons develop physiological properties, not present on the day of grafting, identical to those of normal adult serotonin-containing neurons. These include (a) high input resistance and slow membrane time constant, (b) lack of inward rectification in response to hyperpolarizing current pulses and (c) a potent, 4-aminopyridine-sensitive transient outward rectification. The grafted neurons innervate the host tissue with axons that have a slow conduction velocity and refractoriness. It is suggested that grafted CNS neurons may possess normal physiological properties.

Original languageEnglish (US)
Pages (from-to)162-166
Number of pages5
JournalBrain Research
Volume364
Issue number1
DOIs
StatePublished - Jan 29 1986

Keywords

  • raphe
  • serotonin (5-HT)
  • transplant

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Fetal raphe neurons grafted into the hippocampus develop normal adult physiological properties'. Together they form a unique fingerprint.

Cite this