Filamentous phage assembly: membrane insertion of the major coat protein.

P. Model, M. Russel, J. D. Boeke

Research output: Contribution to journalArticlepeer-review


The assembly of filamentous bacteriophages has been studied in cells infected by wild-type and mutant phage; host mutants defective in bacteriophage assembly have also been isolated. Phage assembly takes place at the membrane, and requires insertion of the viral major coat protein. We present data on the physiology of this process and on the effects of amino acid sequence variations near to the coat protein amino terminus on membrane insertion, processing, and phage assembly.

Original languageEnglish (US)
Pages (from-to)389-400
Number of pages12
JournalProgress in clinical and biological research
StatePublished - 1981

ASJC Scopus subject areas

  • General Medicine


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