@article{45d5a802de7b431d9e5c4b2b42398776,
title = "Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells",
abstract = "A 1,2-dioxolane (FINO2) was identified as a lead compound from a screen of organic peroxides. FINO2 does not induce apoptosis, but instead initiates ferroptosis, an iron-dependent, oxidative cell death pathway. Few compounds are known to induce primarily ferroptosis. In contrast to the perceived instability of peroxides, FINO2 was found to be thermally stable to at least 150 °C. FINO2 was more potent in cancer cells than nonmalignant cells of the same type. One of the enantiomers was found to be more responsible for the observed activity.",
author = "Abrams, {Rachel P.} and Carroll, {William L.} and Woerpel, {K. A.}",
note = "Funding Information: We thank J. Beutler and his laboratory (National Cancer Institute, National Institutes of Health) for performing the initial screen of peroxide compounds. We thank the Developmental Therapeutic Program of the National Cancer Institute for performing the in vitro 60-cell line screen with FINO2. We thank D. Morrison (NYU) and J. Meyer (NYU) for helpful discussions and technical assistance. We thank the Cytometry and Cell Sorting Core (NYU) and Q. Jiang (NYU) for technical assistance. Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",
year = "2016",
month = may,
day = "20",
doi = "10.1021/acschembio.5b00900",
language = "English (US)",
volume = "11",
pages = "1305--1312",
journal = "ACS Chemical Biology",
issn = "1554-8929",
publisher = "American Chemical Society",
number = "5",
}