Five-year clinical outcomes of combined phacoemulsification and trabectome surgery at a single glaucoma center

Hamed Esfandiari, Priyal Shah, Pooya Torkian, Ian P. Conner, Joel S. Schuman, Kiana Hassanpour, Nils A. Loewen

    Research output: Contribution to journalArticlepeer-review


    Purpose: To analyze the 5-year results of trabectome ab interno trabeculectomy of a single glaucoma center. Method: In this retrospective interventional single-center case series, data of 93 patients undergoing ab interno trabeculotomy between September 2010, and December 2012 were included. Kaplan-Meier analysis was performed using success criteria defined as postoperative intraocular pressure (IOP) ≤ 21 mmHg, and > 20% reduction from preoperative IOP, and no need for further glaucoma surgery. Risk factors for failure were identified using Cox proportional hazards ratio (HR). Results: The retention rate for 5-year follow-up was 66%. The cumulative probability of success at 1, 2, 3, 4, and 5 years was 82.6%, 76.7%, 73.9%, 72.3%, and 67.5%. Risk factors for failure were lower baseline IOP (HR = 0.27, P = 0.001), younger age (HR = 0.25, P = 0.02), and higher central corneal thickness (HR = 0.18, P = 0.01). Exfoliative glaucoma was associated with a higher success rate (HR = 0.39, P = 0.02). IOP was decreased significantly from 20.0 ± 5.6 mmHg at baseline to 15.6 ± 4.6 mmHg at 5-year follow-up (P = 0.001). The baseline number of glaucoma medications was 1.8 ± 1.2, which decreased to 1.0 ± 1.2 medications at 5 years. Conclusion: Trabectome surgery was associated with a good long-term efficacy and safety profile in this single-center case series with a high retention rate.

    Original languageEnglish (US)
    Pages (from-to)357-362
    Number of pages6
    JournalGraefe's Archive for Clinical and Experimental Ophthalmology
    Issue number2
    StatePublished - Feb 4 2019


    • Ab interno trabeculectomy
    • Long-term outcomes
    • MIGS
    • Microinvasive glaucoma surgeries
    • Trabectome surgery

    ASJC Scopus subject areas

    • Ophthalmology
    • Sensory Systems
    • Cellular and Molecular Neuroscience


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