Flexible electronic bands for the dynamic optical spectroscopic assessment of systemic lupus erythematosus in finger joints

Youngwan Kim, Alessandro Marone, George Danias, Kayla E. Neville, Andrea T. Frantz, Teja Kapoor, Laura Geraldino-Pardilla, Hyun K. Kim, Anca D. Askanase, Ioannis Kymissis, Andreas H. Hielscher

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    We have developed a system of flexible optical imaging bands that can be used to assess the effects of systemic lupus erythematosus (SLE) on finger joints. Each imaging band consists of four pairs of light sources and a photodetector. The light sources contain three different light emitting diodes with wavelengths of 530 nm, 655 nm and 940 nm. Two of these imaging bands are wrapped around the proximal interphalangeal (PIP) joints of the index-, middle-, and ringfingers. The imaging bands gather transmitted and reflected light intensities from the tissues for ∼ 4 minutes including two venous occlusions. This results in hemodynamic time traces for all source-detector pairs. From theses traces a rise, plateau, and fall time are calculated. We found that, on average, signals obtained from SLE patients displayed a shorter rise time and longer plateau time as compared to signals from healthy controls. Performing a two-dimensional linear discriminant analysis on the rise and plateau times, we obtained the best specificity of 89% and the best sensitivity of 76 %. Area under the receiver operating characteristic (ROC) curve is 0.86.

    Original languageEnglish (US)
    Title of host publicationOptical Diagnostics and Sensing XIX
    Subtitle of host publicationToward Point-of-Care Diagnostics
    EditorsGerard L. Cote
    PublisherSPIE
    ISBN (Electronic)9781510624122
    DOIs
    StatePublished - 2019
    EventOptical Diagnostics and Sensing XIX 2019: Toward Point-of-Care Diagnostics - San Francisco, United States
    Duration: Feb 4 2019Feb 5 2019

    Publication series

    NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    Volume10885
    ISSN (Print)1605-7422

    Conference

    ConferenceOptical Diagnostics and Sensing XIX 2019: Toward Point-of-Care Diagnostics
    CountryUnited States
    CitySan Francisco
    Period2/4/192/5/19

    Keywords

    • Absorption
    • Dynamic diffuse optical imaging
    • Flexible optical imaging band
    • Hemodynamic change
    • Linear discriminant analysis
    • Receiver operating characteristic
    • Systemic lupus erythematosus

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Radiology Nuclear Medicine and imaging

    Fingerprint Dive into the research topics of 'Flexible electronic bands for the dynamic optical spectroscopic assessment of systemic lupus erythematosus in finger joints'. Together they form a unique fingerprint.

    Cite this