TY - GEN
T1 - Flexible electronic bands for the dynamic optical spectroscopic assessment of systemic lupus erythematosus in finger joints
AU - Kim, Youngwan
AU - Marone, Alessandro
AU - Danias, George
AU - Neville, Kayla E.
AU - Frantz, Andrea T.
AU - Kapoor, Teja
AU - Geraldino-Pardilla, Laura
AU - Kim, Hyun K.
AU - Askanase, Anca D.
AU - Kymissis, Ioannis
AU - Hielscher, Andreas H.
N1 - Publisher Copyright:
© COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.
PY - 2019
Y1 - 2019
N2 - We have developed a system of flexible optical imaging bands that can be used to assess the effects of systemic lupus erythematosus (SLE) on finger joints. Each imaging band consists of four pairs of light sources and a photodetector. The light sources contain three different light emitting diodes with wavelengths of 530 nm, 655 nm and 940 nm. Two of these imaging bands are wrapped around the proximal interphalangeal (PIP) joints of the index-, middle-, and ringfingers. The imaging bands gather transmitted and reflected light intensities from the tissues for ∼ 4 minutes including two venous occlusions. This results in hemodynamic time traces for all source-detector pairs. From theses traces a rise, plateau, and fall time are calculated. We found that, on average, signals obtained from SLE patients displayed a shorter rise time and longer plateau time as compared to signals from healthy controls. Performing a two-dimensional linear discriminant analysis on the rise and plateau times, we obtained the best specificity of 89% and the best sensitivity of 76 %. Area under the receiver operating characteristic (ROC) curve is 0.86.
AB - We have developed a system of flexible optical imaging bands that can be used to assess the effects of systemic lupus erythematosus (SLE) on finger joints. Each imaging band consists of four pairs of light sources and a photodetector. The light sources contain three different light emitting diodes with wavelengths of 530 nm, 655 nm and 940 nm. Two of these imaging bands are wrapped around the proximal interphalangeal (PIP) joints of the index-, middle-, and ringfingers. The imaging bands gather transmitted and reflected light intensities from the tissues for ∼ 4 minutes including two venous occlusions. This results in hemodynamic time traces for all source-detector pairs. From theses traces a rise, plateau, and fall time are calculated. We found that, on average, signals obtained from SLE patients displayed a shorter rise time and longer plateau time as compared to signals from healthy controls. Performing a two-dimensional linear discriminant analysis on the rise and plateau times, we obtained the best specificity of 89% and the best sensitivity of 76 %. Area under the receiver operating characteristic (ROC) curve is 0.86.
KW - Absorption
KW - Dynamic diffuse optical imaging
KW - Flexible optical imaging band
KW - Hemodynamic change
KW - Linear discriminant analysis
KW - Receiver operating characteristic
KW - Systemic lupus erythematosus
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U2 - 10.1117/12.2510305
DO - 10.1117/12.2510305
M3 - Conference contribution
AN - SCOPUS:85066605789
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Optical Diagnostics and Sensing XIX
A2 - Cote, Gerard L.
PB - SPIE
T2 - Optical Diagnostics and Sensing XIX 2019: Toward Point-of-Care Diagnostics
Y2 - 4 February 2019 through 5 February 2019
ER -