Flexible optical imaging band system for the assessment of arthritis in patients with systemic lupus erythematosus

Youngwan Kim, Alessandro Marone, Wei Tang, Yevgeniya Gartshteyn, Hyun K. Kim, Anca D. Askanase, Ioannis Kymissis, Andreas H. Hielscher

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We have developed a flexible optical imaging system (FOIS) to assess systemic lupus erythematosus (SLE) arthritis in the finger joints. While any part of the body can be affected, arthritis in the finger joints is one of the most common SLE manifestations. There is an unmet need for accurate, low-cost assessment of lupus arthritis that can be easily performed at every clinic visit. Current imaging methods are imprecise, expensive, and time consuming to allow for frequent monitoring. Our FOIS can be wrapped around joints, and multiple light sources and detectors gather reflected and transmitted light intensities. Using data from two SLE patients and two healthy volunteers, we demonstrate the potential of this FOIS for assessment of arthritis in SLE patients.

    Original languageEnglish (US)
    Pages (from-to)1651-1665
    Number of pages15
    JournalBiomedical Optics Express
    Volume12
    Issue number3
    DOIs
    StatePublished - Mar 2021

    ASJC Scopus subject areas

    • Biotechnology
    • Atomic and Molecular Physics, and Optics

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