Floating microfluidic gradients

M. A. Qasaimeh, D. Juncker

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We propose a concept for rapid generation of tunable, shear-free, mobile gradients in open space which we define as floating gradient. A microfluidic probe with 4 apertures arranged at the corners of a virtual square, two for injecting fluids and two for aspiration. The simultaneous injection from two apertures results to a head-to-head flow at the center of the MFP, and the formation of a stagnation point, while aspiration by the two other apertures results in hydrodynam-ic confinement of the injected streams, forming a quadrupole-like microfluidic field. The two injected streams are the source and sink, respectively, and a gradient is formed across the shear-free, stagnation point. We show that the gradient is formed rapidly, can be tuned by changing the aspiration flow rate, and can be moved either hydrodynamically by changing the flow ratio between the two aspiration apertures and/or two injection apertures, or can be moved by physically displacing the microfluidic probe. We expect the floating gradient concept to be useful for surface patterning and cell studies.

Original languageEnglish (US)
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages1844-1846
Number of pages3
StatePublished - 2010
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: Oct 3 2010Oct 7 2010

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume3

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period10/3/1010/7/10

Keywords

  • Concentration gradients
  • Microfluidic probe
  • Stagnation point

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Qasaimeh, M. A., & Juncker, D. (2010). Floating microfluidic gradients. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (pp. 1844-1846). (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010; Vol. 3).