Flow chemistry has progressed considerably in recent years from basic laboratory techniques in organic synthetic chemistry to complex, multistep processes in practice. In this perspective review, missing links that represent opportunities for chemists and chemical engineers are examined. New avenues in reaction chemistry are expanding the molecular toolbox, which includes green and cascade catalysis. Next generation engineering concepts such as machine intelligence and sustainable manufacturing have become a reality, opening the door to interdisciplinary work unlike before. Emerging trends that have the potential to start new fields of research and technological advancements are also highlighted. Flow chemistry is rewriting the traditional chemistry laboratory and our scientific discovery infrastructure. Enormous opportunities remain for groundbreaking science and engineering from this exciting field that demands a well-trained workforce for its industrial practice. The groundwork is being laid now for industries of the future such as continuous-flow biologics, biopharmaceuticals, and implementation of the nanomaterials revolution.
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