TY - GEN
T1 - Fluidic-capacitor integrated microfluidic platform to mimic heart beating for generation of functional liver organoids
AU - Wu, Jiaxu
AU - Hirai, Yoshikazu
AU - Kamei, Ken Ichiro
AU - Tsuchiya, Toshiyuki
AU - Tabata, Osamu
N1 - Publisher Copyright:
Copyright © (2018) by Chemical and Biological Microsystems Society. All rights reserved.
PY - 2018
Y1 - 2018
N2 - Liver organoids hold a great potential to understand liver development and contribute for drug screening and toxicological testing. However, current methods to generate organoids provide insufficient liver functions and less reproducibility, due to lack of controllability of cellular microenvironmental cues. To tackle this issue, we focus on one of the environmental cues, pressure stimuli by heart beating, and develop a microfluidic-based cell culture platform integrating a fluidic capacitor to produce pressure stimuli mimicking heart beating. Furthermore, we demonstrate a numerical simulation based on equivalent circuit model for designing the device parameters with sufficient accuracy.
AB - Liver organoids hold a great potential to understand liver development and contribute for drug screening and toxicological testing. However, current methods to generate organoids provide insufficient liver functions and less reproducibility, due to lack of controllability of cellular microenvironmental cues. To tackle this issue, we focus on one of the environmental cues, pressure stimuli by heart beating, and develop a microfluidic-based cell culture platform integrating a fluidic capacitor to produce pressure stimuli mimicking heart beating. Furthermore, we demonstrate a numerical simulation based on equivalent circuit model for designing the device parameters with sufficient accuracy.
KW - Equivalent circuit analysis
KW - Fluidic capacitor
KW - Organoid
KW - Polydimethylsiloxane
KW - Pressure stimulus
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UR - http://www.scopus.com/inward/citedby.url?scp=85079762445&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85079762445
T3 - 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
SP - 1718
EP - 1721
BT - 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PB - Chemical and Biological Microsystems Society
T2 - 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Y2 - 11 November 2018 through 15 November 2018
ER -