Fluorescence molecular tomography of small animals using the radiative transfer equation for curved geometries

Alexander D. Klose, Andreas H. Hielscher

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    We have developed a fluorescence image reconstruction algorithm for three-dimensional whole-body small animal imaging. Our method uses non-contact fluorescent light measurement data on the tissue surface of the animal and reconstructs the three-dimensional unknown luorophore concentration inside the tissue. The image reconstruction technique em-ploys a light propagation model based on the equation of radiative transfer, which is solved on a structured Cartesian grid by a finite-difference method. A blocking-off approach takes the curved tissue surface geometry of the animal into account. Our proposed method has the advantage that fast numerical solvers for the equation of radiative transfer can be used.

    Original languageEnglish (US)
    Title of host publicationBiomedical Topical Meeting, BIO 2006
    PublisherOptical Society of America (OSA)
    ISBN (Print)1557528071, 9781557528070
    DOIs
    StatePublished - 2006
    EventBiomedical Topical Meeting, BIO 2006 - Fort Lauderdale, FL, United States
    Duration: Mar 19 2006Mar 19 2006

    Publication series

    NameOptics InfoBase Conference Papers
    ISSN (Electronic)2162-2701

    Conference

    ConferenceBiomedical Topical Meeting, BIO 2006
    Country/TerritoryUnited States
    CityFort Lauderdale, FL
    Period3/19/063/19/06

    ASJC Scopus subject areas

    • Instrumentation
    • Atomic and Molecular Physics, and Optics

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