FMRI of the prefrontal cortex during overt verbal fluency

Elizabeth A. Phelps, Fahmeed Hyder, Andrew M. Blamire, Robert G. Shulman

Research output: Contribution to journalArticlepeer-review


Verbal fluency is is known to be associated with activity in the left prefrontal cortex. Recent positron emission tomography (PET) results confirmed this finding. In the present study, high resolution functional magnetic resonance imaging (fMRI) was used to further localize activity in the prefrontal cortex related to verbal fluency. Activation was observed in three behavioral tasks: (1) Repeat - subjects repeated words, (2) Opposite - subjects produced the antonym of words, and (3) Generate subjects generated words beginning with a given letter. When comparing Generate with both Repeat and Opposite, we observed small areas of activation in the left inferior frontal gyrus and anterior cingulate, similar to the centers of mass reported using PET. We also found additional activation around the superior frontal sulcus.

Original languageEnglish (US)
Pages (from-to)561-565
Number of pages5
Issue number2
StatePublished - 1997


  • Anterior cingulate
  • Inferior frontal gyrus
  • Prefrontal cortex
  • Superior frontal sulcus
  • Verbal fluency
  • fMRI

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'FMRI of the prefrontal cortex during overt verbal fluency'. Together they form a unique fingerprint.

Cite this