FMRI of the prefrontal cortex during overt verbal fluency

Elizabeth A. Phelps, Fahmeed Hyder, Andrew M. Blamire, Robert G. Shulman

Research output: Contribution to journalArticle

Abstract

Verbal fluency is is known to be associated with activity in the left prefrontal cortex. Recent positron emission tomography (PET) results confirmed this finding. In the present study, high resolution functional magnetic resonance imaging (fMRI) was used to further localize activity in the prefrontal cortex related to verbal fluency. Activation was observed in three behavioral tasks: (1) Repeat - subjects repeated words, (2) Opposite - subjects produced the antonym of words, and (3) Generate subjects generated words beginning with a given letter. When comparing Generate with both Repeat and Opposite, we observed small areas of activation in the left inferior frontal gyrus and anterior cingulate, similar to the centers of mass reported using PET. We also found additional activation around the superior frontal sulcus.

Original languageEnglish (US)
Pages (from-to)561-565
Number of pages5
JournalNeuroReport
Volume8
Issue number2
DOIs
StatePublished - 1997

Keywords

  • Anterior cingulate
  • Inferior frontal gyrus
  • Prefrontal cortex
  • Superior frontal sulcus
  • Verbal fluency
  • fMRI

ASJC Scopus subject areas

  • Neuroscience(all)

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    Phelps, E. A., Hyder, F., Blamire, A. M., & Shulman, R. G. (1997). FMRI of the prefrontal cortex during overt verbal fluency. NeuroReport, 8(2), 561-565. https://doi.org/10.1097/00001756-199701200-00036