Focal Therapy for Prostate Cancer

Neil Mendhiratta, Samir S. Taneja

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    With the increasing rate of detection of localized, low-risk cancers of the prostate, new treatment strategies are required to avoid the morbidity of traditional whole-gland therapy while limiting the risk of significant disease progression. Focal therapy is a promising method of prostate cancer treatment with the potential to bridge the gap between active surveillance and radical treatment. Emerging data regarding oncological and quality of life outcomes from clinical trials are encouraging. Although the majority of contemporary-focal therapy options have yet to demonstrate comparable levels of cancer control as whole-gland or radical therapy, refinements in candidate selection, disease mapping, and accurate targeting of ablative energy to cancer foci may facilitate improvements in oncological outcomes. Some of the remaining challenges of focal therapy, including disease mapping, treatment monitoring, and evaluation at follow-up, may be addressed with advances in MRI sequencing and interpretation techniques. However, critical questions about long-term outcomes remain, which require further exploration before protocols for focal therapy in common clinical practice can be developed.

    Original languageEnglish (US)
    Title of host publicationProstate Cancer
    Subtitle of host publicationScience and Clinical Practice: Second Edition
    PublisherElsevier Inc.
    Pages563-577
    Number of pages15
    ISBN (Print)9780128000779
    DOIs
    StatePublished - 2016

    Keywords

    • Cryoablation
    • Focal therapy
    • High-intensity focused ultrasound
    • Laser ablation
    • Photodynamic therapy

    ASJC Scopus subject areas

    • Medicine(all)

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