Formation of chiral quaternary carbon stereocenters using silylene transfer reactions: Enantioselective synthesis of (+)-5-epi-acetomycin

Stacie A. Calad, K. A. Woerpel

Research output: Contribution to journalArticle

Abstract

(Chemical Equation Presented) Chiral quaternary carbon stereocenters can be established with high diastereoselectivity by a silylene transfer/lreland- Claisen rearrangement. The utility of this method was demonstrated by application to a synthesis of (+)-5-epi-acetomycin.

Original languageEnglish (US)
Pages (from-to)1037-1040
Number of pages4
JournalOrganic Letters
Volume9
Issue number6
DOIs
StatePublished - Mar 15 2007

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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