Fornix-dependent induction of hippocampal CCAAT enhancer-binding protein β and δ co-localizes with phosphorylated cAMP response element-binding protein and accompanies long-term memory consolidation

Stephen M. Taubenfeld, Kjesten A. Wiig, Barbara Monti, Bridget Dolan, Gabriella Pollonini, Cristina M. Alberini

Research output: Contribution to journalArticlepeer-review

Abstract

The cAMP response element-binding protein (CREB) is an evolutionarily conserved transcription regulator essential for long-term memory formation. It is not known, however, whether the molecular events downstream of CREB activation are also conserved. An early, cAMP-dependent event necessary for learning-related long-term synaptic plasticity in the invertebrate Aplysia californica is the induction of the transcription factor CCAAT enhancer-binding protein (C/EBP). Here we show that two homologs in the rat, C/EBPβ and C/EBPδ, are induced at discrete times after inhibitory avoidance learning and co-localize with phosphorylated CREB in the hippocampus. This induction is blocked by fornix lesions, which are known to disrupt activation of CREB in the hippocampus and to impair memory consolidation. These results indicate that C/EBPs are evolutionarily conserved components of the CREB-dependent gene cascade activated in long-term memory.

Original languageEnglish (US)
Pages (from-to)84-91
Number of pages8
JournalJournal of Neuroscience
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2001

Keywords

  • C/EBP
  • CREB
  • Fornix
  • Hippocampus
  • Inhibitory avoidance
  • Learning and memory
  • Lesion
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

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