@article{0b0f3206cd724fbebf0fcf46e47e23ea,
title = "FOXO1 regulates VEGFA expression and promotes angiogenesis in healing wounds",
abstract = "Angiogenesis is a critical aspect of wound healing. We investigated the role of keratinocytes in promoting angiogenesis in mice with lineage-specific deletion of the transcription factor FOXO1. The results indicate that keratinocyte-specific deletion of Foxo1 reduces VEGFA expression in mucosal and skin wounds and leads to reduced endothelial cell proliferation, reduced angiogenesis, and impaired re-epithelialization and granulation tissue formation. In vitro FOXO1 was needed for VEGFA transcription and expression. In a porcine dermal wound-healing model that closely resembles healing in humans, local application of a FOXO1 inhibitor reduced angiogenesis. This is the first report that FOXO1 directly regulates VEGFA expression and that FOXO1 is needed for normal angiogenesis during wound healing.",
keywords = "FOXO, VEGF, angiogenesis, blood vessel, dermal, endothelial, forkhead, minipig, mucosa, skin, vascular endothelial growth factor-A, wound",
author = "Jeon, {Hyeran Helen} and Quan Yu and Yongjian Lu and Evelyn Spencer and Chanyi Lu and Tatyana Milovanova and Yang Yang and Chenying Zhang and Olga Stepanchenko and Vafa, {Rameen P.} and Coelho, {Paulo G.} and Graves, {Dana T.}",
note = "Funding Information: We thank Dr. Faizan Alawi for help in the analysis of minipig histologic sections. We would also like to thank Eunice Han and Richa Pande for assistance with genotyping. This work was supported by a grant (R01DE019108; DTG) from the NIDCR and ITI grant #926-2013 (PGC). Funding Information: We thank Dr RA DePinho for the floxed Foxo1 mice and Dr Keping Xie for the VEGFA reporter construct. We thank Dr. Faizan Alawi for help in the analysis of minipig histologic sections. We would also like to thank Eunice Han and Richa Pande for assistance with genotyping. This work was supported by a grant (R01DE019108; DTG) from the NIDCR and ITI grant #926-2013 (PGC). Publisher Copyright: Copyright {\textcopyright} 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.",
year = "2018",
month = jul,
doi = "10.1002/path.5075",
language = "English (US)",
volume = "245",
pages = "258--264",
journal = "Journal of Pathology",
issn = "0022-3417",
publisher = "John Wiley and Sons Ltd",
number = "3",
}