FOXO1 regulates VEGFA expression and promotes angiogenesis in healing wounds

Hyeran Helen Jeon, Quan Yu, Yongjian Lu, Evelyn Spencer, Chanyi Lu, Tatyana Milovanova, Yang Yang, Chenying Zhang, Olga Stepanchenko, Rameen P. Vafa, Paulo G. Coelho, Dana T. Graves

Research output: Contribution to journalArticlepeer-review

Abstract

Angiogenesis is a critical aspect of wound healing. We investigated the role of keratinocytes in promoting angiogenesis in mice with lineage-specific deletion of the transcription factor FOXO1. The results indicate that keratinocyte-specific deletion of Foxo1 reduces VEGFA expression in mucosal and skin wounds and leads to reduced endothelial cell proliferation, reduced angiogenesis, and impaired re-epithelialization and granulation tissue formation. In vitro FOXO1 was needed for VEGFA transcription and expression. In a porcine dermal wound-healing model that closely resembles healing in humans, local application of a FOXO1 inhibitor reduced angiogenesis. This is the first report that FOXO1 directly regulates VEGFA expression and that FOXO1 is needed for normal angiogenesis during wound healing.

Original languageEnglish (US)
Pages (from-to)258-264
Number of pages7
JournalJournal of Pathology
Volume245
Issue number3
DOIs
StatePublished - Jul 2018

Keywords

  • FOXO
  • VEGF
  • angiogenesis
  • blood vessel
  • dermal
  • endothelial
  • forkhead
  • minipig
  • mucosa
  • skin
  • vascular endothelial growth factor-A
  • wound

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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