Free energy self-averaging in protein-sized random heteropolymers

J. Chuang, A. Y. Grosberg, M. Kardar

    Research output: Contribution to journalArticlepeer-review


    Current theories of heteropolymers are inherently macroscopic, but are applied to mesoscopic proteins. To compute the free energy over sequences, one assumes self-averaging--a property established only in the macroscopic limit. By enumerating the states and energies of compact 18, 27, and 36mers on a lattice with an ensemble of random sequences, we test the self-averaging approximation. We find that fluctuations in the free energy between sequences are weak, and that self-averaging is valid at the scale of real proteins. The results validate sequence design methods which exponentially speed up computational design and simplify experimental realizations.

    Original languageEnglish (US)
    Pages (from-to)78104
    Number of pages1
    JournalPhysical Review Letters
    Issue number7
    StatePublished - Aug 13 2001

    ASJC Scopus subject areas

    • General Physics and Astronomy


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