TY - JOUR
T1 - Freezing transition of compact polyampholytes
AU - Pande, Vijay S.
AU - Grosberg, Alexander Yu
AU - Joerg, Chris
AU - Kardar, Mehran
AU - Tanaka, Toyoichi
PY - 1996
Y1 - 1996
N2 - Polyampholytes (PAs) are heteropolymers with long range Coulomb interactions. Unlike polymers with short range forces, PA energy levels have nonvanishing correlations and are thus very different from the random energy model (REM). Nevertheless, if charges in the PA globule are screened as in a regular plasma, PAs freeze in REM fashion. Our results shed light on the potential role of Coulomb interactions in folding and evolution of proteins, which are weakly charged PAs, in particular, making connection with the finding that sequences of charged amino acids in proteins are not random.
AB - Polyampholytes (PAs) are heteropolymers with long range Coulomb interactions. Unlike polymers with short range forces, PA energy levels have nonvanishing correlations and are thus very different from the random energy model (REM). Nevertheless, if charges in the PA globule are screened as in a regular plasma, PAs freeze in REM fashion. Our results shed light on the potential role of Coulomb interactions in folding and evolution of proteins, which are weakly charged PAs, in particular, making connection with the finding that sequences of charged amino acids in proteins are not random.
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U2 - 10.1103/PhysRevLett.77.3565
DO - 10.1103/PhysRevLett.77.3565
M3 - Article
AN - SCOPUS:0001460708
SN - 0031-9007
VL - 77
SP - 3565
EP - 3568
JO - Physical Review Letters
JF - Physical Review Letters
IS - 17
ER -