Frequency-dependent interaural delays in the medial superior olive: Implications for interaural cochlear delays

Mitchell L. Day, Malcolm N. Semple

Research output: Contribution to journalArticle

Abstract

Neurons in the medial superior olive (MSO) are tuned to the interaural time difference (ITD) of sound arriving at the two ears. MSO neurons evoke a strongest response at their best delay (BD), at which the internal delay between bilateral inputs to MSO matches the external ITD. We performed extracellular recordings in the superior olivary complex of the anesthetized gerbil and found a majority of single units localized to the MSO to exhibit BDs that shifted with tone frequency. The relation of best interaural phase difference to tone frequency revealed nonlinearities in some MSO units and others with linear relations with characteristic phase between 0.4 and 0.6 cycles. The latter is usually associated with the interaction of ipsilateral excitation and contralateral inhibition, as in the lateral superior olive, yet all MSO units exhibited evidence of bilateral excitation. Interaural cochlear delays and phase-locked contralateral inhibition are two mechanisms of internal delay that have been suggested to create frequency-dependent delays. Best interaural phase-frequency relations were compared with a cross-correlation model of MSO that incorporated interaural cochlear delays and an additional frequency-independent delay component. The model with interaural cochlear delay fit phasefrequency relations exhibiting frequency-dependent delays with precision. Another model of MSO incorporating inhibition based on realistic biophysical parameters could not reproduce observed frequency-dependent delays.

Original languageEnglish (US)
Pages (from-to)1985-1999
Number of pages15
JournalJournal of neurophysiology
Volume106
Issue number4
DOIs
StatePublished - Oct 2011

Keywords

  • Gerbil
  • Interaural time delay
  • Interaural time difference
  • Sound localization
  • Superior olivary complex

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

Fingerprint Dive into the research topics of 'Frequency-dependent interaural delays in the medial superior olive: Implications for interaural cochlear delays'. Together they form a unique fingerprint.

  • Cite this