Frequency-domain optical tomographic imaging of arthritic finger joints

Andreas H. Hielscher, Hyun Keol Kim, Ludguier D. Montejo, Sabine Blaschke, Uwe J. Netz, Paul A. Zwaka, Gerd Illing, Gerhard A. Müller, Jrgen Beuthan

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We are presenting data from the largest clinical trial on optical tomographic imaging of finger joints to date. Overall we evaluated 99 fingers of patients affected by rheumatoid arthritis (RA) and 120 fingers from healthy volunteers. Using frequency-domain imaging techniques we show that sensitivities and specificities of 0.85 and higher can be achieved in detecting RA. This is accomplished by deriving multiple optical parameters from the optical tomographic images and combining them for the statistical analysis. Parameters derived from the scattering coefficient perform slightly better than absorption derived parameters. Furthermore we found that data obtained at 600 MHz leads to better classification results than data obtained at 0 or 300 MHz.

    Original languageEnglish (US)
    Article number5741853
    Pages (from-to)1725-1736
    Number of pages12
    JournalIEEE Transactions on Medical Imaging
    Volume30
    Issue number10
    DOIs
    StatePublished - Oct 2011

    Keywords

    • Computer aided diagnostics
    • light propagation in tissue
    • optical tomography
    • rheumatoid arthritis (RA)

    ASJC Scopus subject areas

    • Software
    • Radiological and Ultrasound Technology
    • Computer Science Applications
    • Electrical and Electronic Engineering

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