Frequency domain optical tomography based on the equation of radiative transfer

Kui Ren, Guillaume Bal, Andreas H. Hielscher

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Optical tomography consists of reconstructing the spatial distribution of absorption and scattering properties of a medium from surface measurements of transmitted light intensities. Mathematically, this problem amounts to parameter identification for the equation of radiative transfer (ERT) with diffusion-type boundary measurements. Because they are posed in the phase-space, radiative transfer equations are quite challenging to solve computationally. Most past works have considered the steady-state ERT or the diffusion approximation of the ERT. In both cases, substantial cross-talk has been observed in the reconstruction of the absorption and scattering properties of inclusions. In this paper, we present an optical tomographic reconstruction algorithm based on the frequency-domain ERT. The inverse problem is formulated as a regularized least-squares minimization problem, in which the mismatch between forward model predictions and measurements is minimized. The ERT is discretized by using a discrete ordinates method for the directional variables and a finite volume method for the spatial variables. A limited-memory quasi-Newton algorithm is used to minimize the least-squares functional. Numerical simulations with synthetic data show that the cross-talk between the two optical parameters is significantly reduced in reconstructions based on frequency-domain data as compared to those based on steady-state data.

    Original languageEnglish (US)
    Pages (from-to)1463-1489
    Number of pages27
    JournalSIAM Journal on Scientific Computing
    Volume28
    Issue number4
    DOIs
    StatePublished - 2006

    Keywords

    • Discrete ordinates method
    • Equation of radiative transfer
    • Finite volume method
    • Generalized minimal residual algorithm
    • Inverse problems
    • Numerical optimization
    • Optical tomography
    • Photon density waves
    • Regularization

    ASJC Scopus subject areas

    • Computational Mathematics
    • Applied Mathematics

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