Frequency domain optical tomography in human tissue

Yuqi Yao, Yao Wang, Yaling Pei, Wenwu Zhu, Jenhun Hu, Randall L. Barbour

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper, a reconstruction algorithm for frequency-domain optical tomography in human tissue is presented. A fast and efficient multigrid finite difference (MGFD) method is adopted as a forward solver to obtain the simulated detector responses and the required imaging operator. The solutions obtained form MGFD method for 3D problems with weakly discontinuous coefficients are compared with analyzed solutions to determine the accuracy of the numerical method. Simultaneous reconstruction of both absorption and scattering coefficients for tissue-like media is accomplished by solving a perturbation equation using the Born approximation. This solution is obtained by a conjugate gradient descent method with Tikhonov regularization. Two examples are given to show the quality of the reconstruction results. Both involve the examination of anatomically accurate optical models of tissue derived from segmented 3D magnetic resonance images to which have been assigned optical coefficients to the designated tissue types. One is a map of a female breast containing two small 'added pathologies', such as tumors. The other is a map of the brain containing a 'local bleeding' area, representing a hemorrhage. The reconstruction results show that the algorithm is computationally practical and can yield qualitatively correct geometry of the objects embedded in the simulated human tissue. Acceptable results are obtained even when 10% noise is present in the data.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsRandall L. Barbour, Mark J. Carvlin, Michael A. Fiddy
Pages254-266
Number of pages13
StatePublished - 1995
EventExperimental and Numerical Methods for Solving Ill-Posed Inverse Problems: Medical and Nonmedical Applications - San Diego, CA, USA
Duration: Jul 10 1995Jul 11 1995

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume2570
ISSN (Print)0277-786X

Other

OtherExperimental and Numerical Methods for Solving Ill-Posed Inverse Problems: Medical and Nonmedical Applications
CitySan Diego, CA, USA
Period7/10/957/11/95

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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  • Cite this

    Yao, Y., Wang, Y., Pei, Y., Zhu, W., Hu, J., & Barbour, R. L. (1995). Frequency domain optical tomography in human tissue. In R. L. Barbour, M. J. Carvlin, & M. A. Fiddy (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (pp. 254-266). (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 2570).