Frequency domain tomography in small animals with the equation of radiative transfer

Kui Ren, Bryte Moa-Anderson, Guillaume Bal, Xuejun Gu, Andreas H. Hielscher

    Research output: Contribution to journalConference articlepeer-review


    We have developed a model-based iterative image reconstruction scheme based on the equation of radiative transfer in the frequency domain for the applications in small animal optical tomographic imaging. To test the utility of such a code in small animal imaging we have furthermore developed a numerical phantom of a mouse. In simulation studies using this and other phantoms, we found that to make truly use of phase information in the reconstruction process modulation frequencies well above 100 MHz are necessary. Only at these higher frequencies the phase shifts introduced by the lesions of interest are large enough to be measured. For smaller frequencies no substantial improvements over steady-state systems are achieved in small geometries typical for small animal imaging.

    Original languageEnglish (US)
    Article number22
    Pages (from-to)111-120
    Number of pages10
    JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    StatePublished - 2005
    EventOptical Tomography and Spectroscopy of Tissue VI - San Jose, CA, United States
    Duration: Jan 23 2005Jan 26 2005


    • Discrete ordinate
    • Equation of radiative transfer
    • Finite volume method
    • Inverse problems
    • Optical tomography
    • Small animal imaging

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Radiology Nuclear Medicine and imaging


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