From a melt of rings to chromosome territories: The role of topological constraints in genome folding

Jonathan D. Halverson, Jan Smrek, Kurt Kremer, Alexander Y. Grosberg

    Research output: Contribution to journalReview article

    Abstract

    We review pro and contra of the hypothesis that generic polymer properties of topological constraints are behind many aspects of chromatin folding in eukaryotic cells. For that purpose, we review, first, recent theoretical and computational findings in polymer physics related to concentrated, topologically simple (unknotted and unlinked) chains or a system of chains. Second, we review recent experimental discoveries related to genome folding. Understanding in these fields is far from complete, but we show how looking at them in parallel sheds new light on both.

    Original languageEnglish (US)
    Article number022601
    JournalReports on Progress in Physics
    Volume77
    Issue number2
    DOIs
    StatePublished - Feb 2014

    Keywords

    • DNA
    • biological physics
    • chromatin
    • genome
    • genome folding
    • polymer physics
    • protein folding

    ASJC Scopus subject areas

    • Physics and Astronomy(all)

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