Functional DNAzymes organized into two-dimensional arrays

Alejandra V. Garibotti; Scott M. Knudsen; Andrew D. Ellington; Nadrian C. Seeman

doi:10.1021/nl0609955

Functional DNAzymes organized into two-dimensional arrays

Alejandra V. Garibotti, Scott M. Knudsen, Andrew D. Ellington, Nadrian C. Seeman

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

DNAzymes are catalytically active DNA molecules, which have previously been described in solution. Here, we organize these molecules into a series of two-dimensional (2D) arrays using a periodic arrangement of DNA structures based on the DNA double crossover motif. We demonstrate by means of atomic force microscopy that the DNAzymes are organized according to the design and that they retain their activity when attached in linear strings within the context of the 20 array.

Original language	English (US)
Pages (from-to)	1505-1507
Number of pages	3
Journal	Nano Letters
Volume	6
Issue number	7
DOIs	https://doi.org/10.1021/nl0609955
State	Published - Jul 2006

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl0609955

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abstract = "DNAzymes are catalytically active DNA molecules, which have previously been described in solution. Here, we organize these molecules into a series of two-dimensional (2D) arrays using a periodic arrangement of DNA structures based on the DNA double crossover motif. We demonstrate by means of atomic force microscopy that the DNAzymes are organized according to the design and that they retain their activity when attached in linear strings within the context of the 20 array.",

author = "Garibotti, {Alejandra V.} and Knudsen, {Scott M.} and Ellington, {Andrew D.} and Seeman, {Nadrian C.}",

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AU - Knudsen, Scott M.

AU - Ellington, Andrew D.

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Functional DNAzymes organized into two-dimensional arrays

Abstract

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