Functional DNAzymes organized into two-dimensional arrays

Alejandra V. Garibotti, Scott M. Knudsen, Andrew D. Ellington, Nadrian C. Seeman

Research output: Contribution to journalArticle


DNAzymes are catalytically active DNA molecules, which have previously been described in solution. Here, we organize these molecules into a series of two-dimensional (2D) arrays using a periodic arrangement of DNA structures based on the DNA double crossover motif. We demonstrate by means of atomic force microscopy that the DNAzymes are organized according to the design and that they retain their activity when attached in linear strings within the context of the 20 array.

Original languageEnglish (US)
Pages (from-to)1505-1507
Number of pages3
JournalNano Letters
Issue number7
StatePublished - Jul 1 2006


ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

Cite this

Garibotti, A. V., Knudsen, S. M., Ellington, A. D., & Seeman, N. C. (2006). Functional DNAzymes organized into two-dimensional arrays. Nano Letters, 6(7), 1505-1507.