Functional inactivation of dorsal hippocampus impairs active place avoidance in rats

Jose M. Cimadevilla, Andre A. Fenton, Jan Bures

Research output: Contribution to journalArticlepeer-review


This paper assesses the contribution of hippocampus to the spatial orientation of Long-Evans rats in a new place avoidance task. The animals learn to avoid a mild footshock in a segment of a rotating arena. Since the punished region is defined in the coordinate system of the stationary room the subject is forced to move away from the prohibited segment even if it is immobile. After bilateral injection of tetrodotoxin (5 ng in 1 μl of saline) into the dorsal hippocampus rats were not able to avoid the punished place while a similar injection of saline did not affect performance. The results suggest the task is suitable for assessing the hippocampus-dependent spatial abilities of laboratory rodents. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)53-56
Number of pages4
JournalNeuroscience letters
Issue number1
StatePublished - May 5 2000


  • Functional ablation
  • Hippocampus
  • Place avoidance
  • Rat
  • Spatial orientation
  • Tetrodotoxin

ASJC Scopus subject areas

  • General Neuroscience


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