Functional lactide monomers: Methodology and polymerization

Warren W. Gerhardt, David E. Noga, Kenneth I. Hardcastle, Andrés J. García, David M. Collard, Marcus Weck

Research output: Contribution to journalArticlepeer-review


Side-chain-functionalized lactide analogues have been synthesized from commercially available amino acids and polymerized using stannous octoate as a catalyst. The synthetic strategy presented allows for the incorporation of any protected amino acid for the preparation of functionalized diastereomerically pure lactide monomers. The resulting functionalized cyclic monomers can be homopolymerized and copolymerized with lactides and then quantitatively deprotected forming new functional poly(lactide)-based materials. This strategy allows for the introduction of functional groups along a poly(lactide) (PLA) backbone that after deprotection can be viewed as chemical handles for further functionalization of PLA, yielding improved biomaterials for a variety of applications.

Original languageEnglish (US)
Pages (from-to)1735-1742
Number of pages8
Issue number6
StatePublished - Jun 2006

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry


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